ACP

Cypermethrin is synthetic pesticide that has been in use for more than a decade. A study of a low-dose exposure of this pesticide in rat administered, followed by determination of enzyme rate constant will highlight early catalytic changes that generally accompanied a toxic response in the animal. Even though, cypermethrin was used at 5 mM, for durations of 6, 12 and 24 h in the different groups of rats, results of the study indicate that simultaneous with changes in enzyme activity and rate constant of selected enzymes in selected tissues and serum. Tissue specific changes in the enzyme rate constant were suggestive of the lack of tissue resistance to pyrethroids.  Key words: Cypermethrin; ALT; AST; ALP; ACP; GGT

  Alpha-cypermethrin (α-CYP) a synthetic pyrethroid (type-II) pesticide. Pyrethroid insecticides have been used in agricultural and home formulations for more than 30 years. Despite their extensive worldwide use, there are relatively few reports of the kinetic profile. Dissolved in alcohol was given to male albino rat for 24hr individual groups at 5, 10, 25 and 50mM dose for each group. The animals were sacrificed after 24hr duration. Biochemical studies were observed in testis. Increased the activity of alkaline phosphatase(ALP) at 24hr duration, while decreased acid phosphatase(ACP) at respective duration. Therefore low doses of alpha-cypermethrin altered testicular biomarker enzyme activities. This may interfere in the functioning of the reproductive system of albino rat.