Flurbiprofen

The aim of this study was to develop a pH independent enteric coated extended release pellets containing flurbiprofen. The drug loaded pellets were prepared by using extrusion/ spheronization method using microcrystalline cellulose in combination with dicalcium phosphate dihydrate as pellet forming agents. Core pellets were coated with polymers Eudragit RS-100 and Eudragit RL-100 in a fluid bed coater to achieve a sustainable release for 24 hours. The pellets were subjected to physicochemical studies, SEM study, in-vitro drug release, kinetic studies and stability studies. DSC and FTIR studies shown there was no interaction between drug and polymers. The physicochemical properties of pellets were found within the limits. The drug release from the optimized formulations was extended for a period of 24 hrs i.e. first 2 hrs no drug release was observed and gradually drug release was increased up to 24 hrs. From the above results, achievement of site specific release to lower part of gastrointestinal tract might be due to Eudragit RL 100. The optimized formulation was subjected to stability studies and showed no significant changes in drug content, physicochemical parameters and release pattern. In conclusion, development of novel and good approach to achieve the site specific release of drug Flurbiprofen.

Effective and advantageous Hydrotropic Solubilization technique has been developed for the estimation of two drugs i.e, Flurbiprofen and Glipizide in bulk and its pharmaceutical formulations. Hydrotropic Solubilization technique is one of the aqueous solubility enhancing methods employed for the poorly water soluble drugs and found to be simple, precise and cost effective. Solvents like Piperazine, Urea, Sodium Salicylate, Sodium benzoate etc are the commonly used as hydrotropic solventsin different concentrations. The use of these hydrotropic solvents are of proper choice since the use of organic solvents can be reduced as it is hazardous, costlier and causes environmental pollution. In this context, 1M piperazine has been used as a solubilizing agent to enhance solubility of both the drugs, Flurbiprofen and Glipizide. The absorption maximum of Flurbiprofen and Glipizide was found to be at 246nm and276nm in Zero order derivative spectrum (Method A), calculation of Area Under Curve (AUC)(Method B) was done in the wavelength range of 236-256nm for Flurbiprofen and 266-286nm for Glipizide. The Beer-Lambert’s law has been followed in the concentration range of 2-10µg/ml for Flurbiprofen and 5-35µg/ml for Glipizide for both the methods. The methods were validated as per ICH guidelines and all the validation parameters were found to be within the acceptable range. The developed methods were successfully practiced to estimate the amount of Flurbiprofen and Glipizide in bulk and pharmaceutical dosage forms in routine analysis.

In the present study, Flurbiprofen was used for preparing Floating dosage form that are designed to retain in stomach for a long time and have developed as a Floating drug delivery system by using various polymers like Carbopol 940 and HPMC K4M to enhance the bioavailability and therapeutic efficacy of Flurbiprofen. The mechanism of action of Flurbiprofen is Non selective COX inhibitor which inhibits the prostaglandin synthesis. Sodium bicarbonate and citric acid was incorporated as a gas generating agent. The direct compression method is used in present work. The formulation was optimized on basis of acceptable tablet properties like optimum hardness, uniform thickness, consistent weight uniformity and low friability. The prepared formulation shows better and significant result all the evaluated parameter. 

The aim of present study,  To formulate and characterized  proniosome contain flurbiprofen in a gel formulation for the treatment of rheumatoid arthritis and enhanced skin targeted effect, sustained & prolonged drug release, enhanced skin bioavailability by using different type of non ionic surfactant & cholesterol. The batches were designed using Box Behnken Design and prepared by coacervation phase separation method. Optimized formulation (PNGopt) showed drug entrapment efficiency of 74.46% and particle size 215nm. In-vitro drug release from PNGopt was found to be 84.15 in 24 hrs. The In-vitro drug release was best explained by zero order kinetics as the plot showed highest linearity and release was governed by Quasi Fickian diffusion.

Flurbiprofen Non-steroidal anti-inflammatory drugs (NSAIDS) drug has half-life of about 3 to 6 hrs. The present study aims to formulate and evaluate poorly soluble drug Flurbiprofen using solid dispersion based tablet. Various studies have been done in attempt to improve the solubility’s of Poorly water soluble drugs. The advent of solid dispersion technique provides a unique approach to particle size reduction and increased rates of dissolution. The compatibility studies of the drug and polymers were studied by IR spectroscopy and results suggested no interaction between drug and polymers. Solid dispersions of Flurbiprofen were prepared by common solvent method using Hydroxy Propyl Cellulose (HPC), Polyvinyl Pyrrolidone K-30(PVP) and Mannitol Fast dissolution observed with Mannitol as compared to HPC and PVP. Formulations F3, F6 and F9 containing PVP, HPC and Mannitol along with drug in 1: 6 ratios were used to formulate tablets. Formulation F9 containing drug and Mannitol showed highest dissolution of 81.11% in 1 hour  due to amorphous nature of drug in presence of polymer. Formulation F3 containing drug and PVP in 1 : 6 ratio showed 73.05% drug release  because of the formation of aggregates. Formulation F6 containing drug and HPC showed only 61.65% drug release due to the crystalline of the drug, low solubility of the drug. Results indicate that formulations prepared by the technique of solid dispersion showed increase in the dissolution of Poorly water soluble drug. Key word: Solid dispersion; Flurbiprofen; Micronization; Compatibility studies.