Carbopol 940.

The present study was aimed to formulate Solid lipid nanoparticles loaded thermo-reversible nasal In-situ gel containing Hibiscus Rosa sinensis extract by cold technique to impart better anti-depressant activity. It can improve the penetration of drug to CNS and shows faster pharmacological action. Thermo- reversible nasal In-situ gel were prepared by Poloxamer188 (PluronicF68) with mucoadhesive polymer polymers Carbopol 940. Nasal drug delivery systems are better imparts the Anti-depressant activity. The pH of the formulations was found to be within the range of 6.4 to 7.4. Viscosity of solid lipid nanoparticles loaded thermo- reversible nasal in-situ gel was found to be (212 cps to 409.6) for the sol, where as for the gels it was upto (38969 cps). The Spreadability SLN loaded In-situ nasal gel was found to be 25.19 (gm.cm/sec).The optimized formulation showed a drug release of 72.17% in 5hrs.

In the present study, Flurbiprofen was used for preparing Floating dosage form that are designed to retain in stomach for a long time and have developed as a Floating drug delivery system by using various polymers like Carbopol 940 and HPMC K4M to enhance the bioavailability and therapeutic efficacy of Flurbiprofen. The mechanism of action of Flurbiprofen is Non selective COX inhibitor which inhibits the prostaglandin synthesis. Sodium bicarbonate and citric acid was incorporated as a gas generating agent. The direct compression method is used in present work. The formulation was optimized on basis of acceptable tablet properties like optimum hardness, uniform thickness, consistent weight uniformity and low friability. The prepared formulation shows better and significant result all the evaluated parameter.