Poloxamer188

The present study was aimed to formulate Solid lipid nanoparticles loaded thermo-reversible nasal In-situ gel containing Hibiscus Rosa sinensis extract by cold technique to impart better anti-depressant activity. It can improve the penetration of drug to CNS and shows faster pharmacological action. Thermo- reversible nasal In-situ gel were prepared by Poloxamer188 (PluronicF68) with mucoadhesive polymer polymers Carbopol 940. Nasal drug delivery systems are better imparts the Anti-depressant activity. The pH of the formulations was found to be within the range of 6.4 to 7.4. Viscosity of solid lipid nanoparticles loaded thermo- reversible nasal in-situ gel was found to be (212 cps to 409.6) for the sol, where as for the gels it was upto (38969 cps). The Spreadability SLN loaded In-situ nasal gel was found to be 25.19 (gm.cm/sec).The optimized formulation showed a drug release of 72.17% in 5hrs.

The aim of the study was to improve the solubility of aceclofenac, which is poorly water soluble drug belongs to BCS class-II. Aceclofenac appears to be particularly well tolerated among the NSAIDs, with a lower incidence of gastrointestinal adverse effects. For poorly soluble orally administered drugs, the rate of absorption is often controlled by the rate of dissolution. To improve the solubility of drug by solid dispersions were prepared with different methods like physical mixture, kneading method and solvent evaporation method with various carriers like poloxamer188, poloxamer407 and PEG 6000 in different ratios from 1:1 to 1:5. The prepared formulations were evaluated for physicochemical characteristics, characterized by differential scanning calorimetry (DSC), X-ray diffraction (XRD), in-vitro dissolution studies and saturation solubility. Based on the evaluation parameters poloxamer407 in ratio of 1:5 through solvent evaporation method was optimized and formulated into tablets by direct compression method. These tablets showed a higher in-vitro dissolution drug release which is 99.62% in 30 minutes when compared with pure drug which showed 26.62% in 60 minutes, whereas marketed tablet (Hifenac) shows 99.64±0.10% in 40 minutes. Hence it was concluded that solid dispersion of aceclofenac drug by using polaxamer 407 with solvent evaporation method enhances solubility, absorption rate and increase bioavailability of the aceclofenac drug.