Multiparticulate Sustain Drug Delivery System of Flurbiprofen

The aim of this study was to develop a pH independent enteric coated extended release pellets containing flurbiprofen. The drug loaded pellets were prepared by using extrusion/ spheronization method using microcrystalline cellulose in combination with dicalcium phosphate dihydrate as pellet forming agents. Core pellets were coated with polymers Eudragit RS-100 and Eudragit RL-100 in a fluid bed coater to achieve a sustainable release for 24 hours. The pellets were subjected to physicochemical studies, SEM study, in-vitro drug release, kinetic studies and stability studies. DSC and FTIR studies shown there was no interaction between drug and polymers. The physicochemical properties of pellets were found within the limits. The drug release from the optimized formulations was extended for a period of 24 hrs i.e. first 2 hrs no drug release was observed and gradually drug release was increased up to 24 hrs. From the above results, achievement of site specific release to lower part of gastrointestinal tract might be due to Eudragit RL 100. The optimized formulation was subjected to stability studies and showed no significant changes in drug content, physicochemical parameters and release pattern. In conclusion, development of novel and good approach to achieve the site specific release of drug Flurbiprofen.