Floating

The objective of this research work was to formulate and evaluate the floating drug delivery system containing Risperidone drug, to improve oral bioavailability by increasing gastric residence time. Gastroretentive drug delivery system was developed by using Gum karaya & HPMC K 200M polymers. Formulations were prepared by using direct compression method. Optimization study was performed by using 32  full factorial design. The formulated floating tablets batches were evaluated for physicochemical parameters like hardness, thickness, weight variation, friability, drug content, floating lag time and swelling index. All prepared batches shown good in-vitro buoyancy studies and acceptable result of  for various parameters. Comparing the all the formulations, formulation R6 was considered as optimized formulation which exhibited 99.41% of drug release in 12 hours, floating lag time of 2.14 ± 2.0 minutes total floating time of over 12 hours.

The concept of the sintering technique in the pharmaceutical sciences is relatively new.The objective of the present study was to prepare and evaluate thermally sintered gastro retentive floating matrix tablets of Atazanavir sulphate. The formulations were prepared by direct compression method using EC N100 and HPMC K100 as polymer. The prepared tablets were exposed at two different temperatures like 500C and 600C for two different periods like 1.5 hr and 3 hr in a hot air oven. Effects of sintering conditions were studied on in vitro dissolution studies, hardness, friability, floating lag time and total floating time. The sintering temperature and the sintering time markedly affected the drug release properties. The release rate of the drug was inversely related to the sintering temperature and the sintering time. The hardness was increased with increase in sintering temperature and duration of sintering; but friability of tablets was found to be decreased with increasing sintering time. Floating lag time was inversely proportional to the sintering temperature and sintering time, whereas total floating time was directly proportional to the sintering temperature and sintering time. The formulation F2 sintered at 600 for 3 h was selected as an optimized formulation based on the drug retarding properties and the optimized formulation followed Fickian diffusion mechanism with Korsmeyer-Peppas release kinetics. FTIR and DSC studies were used to characterize the optimized formulation and those studies showed no evidence on interaction between the drug and polymer used.