drug release.

The present study deals with application of melt granulation technology to develop sustained release formulation of aceclofenac with lipidic excipients (Compritol 888 ATO). This approach is concerned with the use of minimum number of excipients to reduce the tablet weight and increase the compatibility of the drug. The continuous melt granulation/extrusion was done by optimizing the formulation as well as processing parameter such as drug loading, operating temperature, screw speed and feed rate during the process. The FTIR study revealed that there is no chemical interaction exists in between the drug and lipidic excipients while DSC and XRD studies exhibited crystalline state of the drug after melt granulation. The scanning electron microscopic examination of melt extrudates revealed the agglomerated particles with porous network and rough surface. The developed tablet (80% drug loading) has weight of  250 mg (mini tablet) containing 200mg of aceclofenac and it showed sustained release profile upto 24h.

The objective of this research work was to formulate and evaluate the floating drug delivery system containing Risperidone drug, to improve oral bioavailability by increasing gastric residence time. Gastroretentive drug delivery system was developed by using Gum karaya & HPMC K 200M polymers. Formulations were prepared by using direct compression method. Optimization study was performed by using 32  full factorial design. The formulated floating tablets batches were evaluated for physicochemical parameters like hardness, thickness, weight variation, friability, drug content, floating lag time and swelling index. All prepared batches shown good in-vitro buoyancy studies and acceptable result of  for various parameters. Comparing the all the formulations, formulation R6 was considered as optimized formulation which exhibited 99.41% of drug release in 12 hours, floating lag time of 2.14 ± 2.0 minutes total floating time of over 12 hours.