floating lag time

The objective of this research work was to formulate and evaluate the floating drug delivery system containing Risperidone drug, to improve oral bioavailability by increasing gastric residence time. Gastroretentive drug delivery system was developed by using Gum karaya & HPMC K 200M polymers. Formulations were prepared by using direct compression method. Optimization study was performed by using 32  full factorial design. The formulated floating tablets batches were evaluated for physicochemical parameters like hardness, thickness, weight variation, friability, drug content, floating lag time and swelling index. All prepared batches shown good in-vitro buoyancy studies and acceptable result of  for various parameters. Comparing the all the formulations, formulation R6 was considered as optimized formulation which exhibited 99.41% of drug release in 12 hours, floating lag time of 2.14 ± 2.0 minutes total floating time of over 12 hours.

The aim of the present work was to develop and optimize gastroretentive floating system of Gemifloxacin mesylate using HPMC polymers, Gelucire 50/13 and Polyox WSR 301 to improve oral bioavailability of Gemifloxacin mesylate floating tablets by increasing gastric residence time. The tablets were prepared by direct compression method. The effect of polymers concentration and viscosity grades of HPMC on drug release profile was evaluated. The result of in vitro dissolution study showed that the drug release profile could be sustained by increasing the concentration of HPMC and Polyox WSR 301. The optimized formulation (F12) containing HPMC K100M, Gelucire 50/13 and Polyox WSR301 showed 99.12% drug release at the end of 12h. The optimized formulations (F12) containing showed desired buoyancy (floating lag time of about 35 seconds and total floating time of >12h). Optimized formulation (F12) followed diffusion controlled zero order kinetics and non-fickian transport of the drug. FTIR studies revealed the absence of any chemical interaction between drug and polymers used.