Gastro retentive

The purpose of this research was to prepare and evaluate a floating drug delivery system of a proton pump inhibitor (pantoprazole sodium). Pantoprazole is a proton pump inhibitor, belongs to group of benzimidazole, used for the treatment of gastric and duodenum ulcers. The core tablets were prepared by direct compression method (effervescent method) by using microcrystalline cellulose, sodium bicarbonate, citric acid, magnesium stearate and HPMC K100 and HPMC K15. The physicochemical parameters like pre-compression and post compression evaluation were performed as per Pharmacopoeial standard and the compatibility study was performed by FTIR and DSC methods. The release data were subjected to different models in order to evaluate their release kinetics and mechanisms. The compatibility study of the prepared Pantoprazole sodium tablets implies the information about no interaction between drug and polymer. The drug release kinetics was observed by Non-Fickian diffusion mechanism. HPMC K100 shows better release properties than HPMC K15. The floating lag time were found to be significantly increased with the increasing concentration of the gas generating agent. After the dissolution study of prepared Pantoprazole sodium floating tablet, it was concluded that the formulations with HPMC K100 shows better controlled release effect than HPMC K15. The release kinetics data implies that the release mechanism of the all formulation was Non-Fickian. The developed floating tablets of pantoprazole sodium may be used in clinic for prolonged drug release for at least 12h, thereby improving the bioavailability and patient compliance.

The concept of the sintering technique in the pharmaceutical sciences is relatively new.The objective of the present study was to prepare and evaluate thermally sintered gastro retentive floating matrix tablets of Atazanavir sulphate. The formulations were prepared by direct compression method using EC N100 and HPMC K100 as polymer. The prepared tablets were exposed at two different temperatures like 500C and 600C for two different periods like 1.5 hr and 3 hr in a hot air oven. Effects of sintering conditions were studied on in vitro dissolution studies, hardness, friability, floating lag time and total floating time. The sintering temperature and the sintering time markedly affected the drug release properties. The release rate of the drug was inversely related to the sintering temperature and the sintering time. The hardness was increased with increase in sintering temperature and duration of sintering; but friability of tablets was found to be decreased with increasing sintering time. Floating lag time was inversely proportional to the sintering temperature and sintering time, whereas total floating time was directly proportional to the sintering temperature and sintering time. The formulation F2 sintered at 600 for 3 h was selected as an optimized formulation based on the drug retarding properties and the optimized formulation followed Fickian diffusion mechanism with Korsmeyer-Peppas release kinetics. FTIR and DSC studies were used to characterize the optimized formulation and those studies showed no evidence on interaction between the drug and polymer used.