Antibacterial activity

The bacterial and fungal inhibitory efficiency of the Argemone mexicana Linn. (Papaveraceae) and Aerva javanica (Burm.f.) Juss. Ex. Schult. (Amaranthaceae) were evaluated against bacterial species like Staphylococus aureus, Streptococcus pyrogens, Klebsiella pneumonia and Escherichia coli and two fungal species such as Aspergillus niger and Penicillium notatum. The susceptibility of the microorganism to the extracts of these plants was compared with each other and with selected antibiotics. All these plants were effective against three of the pathogenic microorganisms. This in vitro study corroborated the antimicrobial activity of the selected plants used in folklore medicine. Key words: Antibacterial activity, Antifungal activity, Disc diffusion method, Well diffusion method.

A new series transition metal complexes of Cu(II), Co(II), Ni(II) and Zn(II)  complexes have been synthesized from 2-(4-amino-5-mercapto-4H-1,2,4-triazol-3-yl)phenol (AMPT). The nature of bonding and the geometry of the complexes have been deduced from elemental analyses, magnetic susceptibility, infrared, electronic, 1H NMR, 13C NMR, and EPR spectral studies. The redox behavior of copper complexes was studied by cyclic voltammetry.  The second harmonic generation (SHG) efficiency was measured by Kurtz and Perry method. The ligand and their metal complexes were screened by Well diffusion method. The interaction of complexes with CT- DNA was investigated by viscosity measurement. Results suggest that all the complexes bind to DNA via an intercalative mode. The DNA cleavage ability of all the complexes was examined on calf thymus (CT-DNA) plasmids using gel electrophoresis experiment in presence of H2O2. From the results it is concluded that all the complexes cleave DNA.

  A series of substituted piperazine derivatives have been synthesized and tested for antibacterial activity. The antibacterial activity was tested against Gram-positive and Gram-negative bacteria strains like B. subtilis, B. pumillis, E. coli, and P. aeruginosa . These entire compounds have been characterized by their IR and 1H NMR spectral data. All synthesized compounds showed significant activity against bacterial strains. The biological screening showed that the compounds Vc, Vd and Ve are the most active ones showing an interesting antibacterial activity.