Vijay Kumar Singh

Oral drug delivery has been known for decades as the most widely utilized route of administration among all the routes. United State Food and Drug Administration (FDA) defined ODT as “a solid dosage form containing medicinal substance or active ingredients which disintegrate rapidly usually within a matter of second when placed upon the tongue. Propranolol is a nonselective beta-adrenergic blocker and is almost completely absorbed following oral administration. However , most of drug is undergoes high first-pass metabolism by the liver and on average, only about 25% of propranolol reaches the systemic circulation. The present study investigated to development of novel fast dissolving tablet of Propranolol HCL which was by first pass metabolism, provide rapid onset of action and increasing the bioavailability of the drug. The fast dissolving tablets were prepared by Direct compression method by using different superdisintegrant like Crosspovidone, crosscarmellose sodium, sodium starch glycolate etc. The advantage of this formulation is such that in case of hypertension attack patient can take the drug without the usage of water. Therefore the main objective of the present work is to develop orodispersible tablets of Propranolol hydrochloride to improve bioavailability, disintegration time, dissolution efficacy and patient compliance.

Drug delivery through oral route is widely accepted through all over world. Mouth dissolving tablet is most suitable tablet than conventional tablet. The main characteristic which is in the favors of mouth dissolving tablet is that there is no need of water to take it. Due to this it become more suitable dosage form for pediatric and geriatric patients. Since bioavailability of mouth dissolving tablet is high than conventional tablet, and mixing of piperine with it make them much more advance dosage form. Due to the addition of piperine in the drug, the dose size is reduced, and enhanced the onset of action. Addition of piperine with norfloxacin also increase the antibacterial activity and make them more effective.