piperine

Drug delivery through oral route is widely accepted through all over world. Mouth dissolving tablet is most suitable tablet than conventional tablet. The main characteristic which is in the favors of mouth dissolving tablet is that there is no need of water to take it. Due to this it become more suitable dosage form for pediatric and geriatric patients. Since bioavailability of mouth dissolving tablet is high than conventional tablet, and mixing of piperine with it make them much more advance dosage form. Due to the addition of piperine in the drug, the dose size is reduced, and enhanced the onset of action. Addition of piperine with norfloxacin also increase the antibacterial activity and make them more effective.

Triphala guggulu contain the amala,baheda,and harde ,pipali, and guggulu in powder form which contain many phytoconstituents other than phenols(gallic acid,ellagic acid) and alkaloids(piperine) and Z-guggulusterone. phenolics are present in good amounts, and several as important anti-oxidant. Piperine is a bioavailability enhancer and guggulusterone as anticholesterimic. Looking into the importance of these ingredients, attempt has been made for simultaneous estimation of piperine, gallic acid, ellagic acid by using HPTLC methods  A simple HPTLC method has been developed for the estimation of galic acid, ellegic acid,piperine &z-gugggulu sterone from methanolic extract of marketed & lab preparation of triphala guggulu these compound in the extracts has been estimated by using HPTLC method the separation was performed on TLC Aluminum Plates precoated with silica gel 60F254,good separation was achieved in the mobile phase of toluene: ethyl acetate :formic acid: methanol(3:3:0.8:0.5)and densiometric determination of galic acid, ellegic acid carried out at 280 nm and piperine was carried out at 337nm&Z-guggulusterone was carried out at 248 nm & compare the these phytoconstituents with other marketed product