Suchita G

Ophthalmic drug delivery is one of the most interesting and challenging endeavours facing the pharmaceutical scientist. The anatomy, physiology and biochemistry of the eye render this organ highly impervious to foreign substances. Various ophthalmic vehicles, such as inserts, ointments, suspensions and aqueous gels, have been developed to lengthen the residence times of instilled dose and enhance ophthalmic bioavailability1. The objective of the present work was to develop an ion activated in situ gelling system of Levofloxacin, a fluoroquinolone derivative used in external infections of the eye. Gellan, alone, was investigated as vehicle for the formulation of eye drops of Levofloxacin (0.5%), which would undergo gelation when instilled into cul-de-sac of the eye and provide sustained release during treatment of ocular infections. The developed formulations were therapeutically efficacious and provide sustained release of the drug during over a 8-hrs period in vitro2.

The importance of mouth and teeth cleanliness has been recognized from the earliest days of civilization to the 21st century. Patients and oral health practitioners are faced with a multitude of mouthwash products containing many different active and inactive ingredients. Making informed decisions as to the suitability of a particular product for a particular patient can be a complex task. Although many popular herbal products have helped to control dental plaque and gingivitis, they have been used for a short time and only as an adjunct to other oral hygiene measures such as brushing and flossing. Various herbal products and their extracts such as Turmeric, Triphala, Neem, Tulsi, etc, have shown significant advantages over the chemical ones. Natural mouthwashes may offer significant advantages over the chemical ones. If such mouthwashes can be formulated which can be easily prepared and used safely by people at home using natural products, it may lead to improvement in the general dental health of the population. We have prepared formulation F1 to F5. Then according to antimicrobial activity and evaluation parameters optimized one formulation.

Hibiscus rosasinensis Linn are used in medicines in emollients and also it is used to treat burning sensations and skin disease. Mucilage of Hibiscus rosasinensis contains L‐rhamnose, D‐galactose, D‐galactouronic acid, and D‐glucuronic acid. The present article is trying to present an investigation is to extract the mucilage from the petals of flower of Hibiscus rosasinensis and use it in a paracetamol tablets as a binder. As the mucilage having granulating and binding properties so it is used in tablets, using paracetamol as a model drug. The Ph of mucilage was found to be 6.5 and all the physicochemical properties i.e. solubility and swelling index was studied. In this investigation wet granulation technique is used for the formation of granules using the above described mucilage which having the concentration of 2%, 5% and 7% w/v to use as a binder.’