Preeti Kothiyal

Floating drug delivery system is suitable for NVP as the absorption and solubility of NVP is high at pH

The present experimental study involves the preparation and characterization of  Orodispersible film of enalapril maleate. In this method HPMCK100 and propylene glycol are used to formulate orodispersible film and two disintegrating agent was used by using solvent casting method. Enalapril maleate is a antihypertensive drug which class of ACE inhibitor (Angiotensin converting enzyme). It is used in the treatment of hypertension congestive heart failure. It show low bioavailability due to high hepatic first pass metabolism so the soft palate drug delivery provide an excellent route to deliver the drug into systemic circulation and the present experimental work to formulate bioadhesive orodispersible of  enalapril maleate to improve the therapeutic efficacy, patient compliance and its bioavailability by avoiding the first pass metabolism. After proper preformulation studies various orodispersible film which were prepared subjected for several evaluation study like thickness, weight uniformity, surface pH, drug uniformity, folding endurance, In vitro disintegration time the drug is rapidly disintegrate within seconds. It means it show that best for the those patient who have difficult to swallowing the drug and .Invitro dissolution  study of prepared orodispersible film was carried out in phosphate buffer 7.4 as a medium and it was clearly observed that the F6 formulation  a best formulation because it rapidly drug release. All the formulation provide a well controlled drug release at a sustainable rate. From the experimental result it was clearly concluded that orodispersible film of enalapril maleate may use as an effective drug delivery with an enhance bioavailability.

In-situ gelling system is a process in which a solution form converted into the gel form after the formulation has been applied at the site. In-situ gel is helpful to produce sustained release of drug. Fluoxetine HCl is a selective serotonin reuptake inhibitor. The current study deals with the preparation, evaluation and optimization of In-situ gel of Fluoxetine HCl for intranasal delivery for the effective treatment of depression. The In-situ gel of Fluxetine HCl was prepared by cold-technique and evaluated for its physical appearance, viscosity, Gel forming temperature, Melting temperature, pH, Spreadability, Swelling index, Drug content and In-vitro release study. In-vitro drug release for optimized formulation was found to be 95.55% of F2 and pH, Drug content, Spreadability, Gelling temperature, Melting temperature were found to be 6.3, 97.6%, 8.0 gmcm/sec, 330C, 790C respectively. The study clearly demonstrated that the Fluoxetine HCl can be successfully delivered through nasal route by preparing in-situ gel. Gel is non-irritating when delivered through nasal route.

The aim of present work was to develop a emulgel for the topical delivery system which is useful in the treatment of vaginal fungal infection. Emulgels having advantage of both emulsion & gels which act as a controlled drug delivery system for topically applied drugs. The Gel in formulations were prepared by dispersing Carbopol 934 & Carbapole 940 in purified water. Then oil phase & aqueous phase of the emulsion were prepared. Both the oily and aqueous phases were heated separately & then oily phase were added to the aqueous phase. add Glutaraldehyde in during of mixing of gel and emulsion in ratio 1:1 to obtain the emulgel. Prepared emulgels was investigated for different parameters. All the prepared emulgels showed acceptable physical properties concerning colour, viscosity, melting point, pH value, and spreadability. The results of in-vitro drug release showed that carbopol 934 was the formula of choice as it showed better drug release & antifungal activity. FTIR studies revealed that drug and all excipients are compatible. The data obtained from in- vitro permeation studies was treated by various conventional mathematical models (zero order, first order, Higuchi and Korsmeyer- peppa’s) to determine the release mechanism from the designed emulgel formulations. Selection of a suitable release model was based on the values of R2 (correlation coefficient), k (release constant) obtained from the curve fitting of release data. It was found that all the formulations follows the first order kinetics. The regression coefficients for the all formulations F1 to F4 of Higuchi plot was found to be almost linear. Key words: Emulgel, tioconazole, antifungal drug, topical drug delivery.

The aim of present work was to develop a self emulsifying emulsion of ketaconazole for the topical delivery system which is useful in the treatment of fungal infection. Prepared SEDDS was investigated for different parameters. All the prepared SEDDS showed acceptable physical properties concerning colour, viscosity, melting point etc. The results of in -vitro drug release showed that carbopol 934 was the formula of choice as it showed better drug release & antifungal activity. The percentage cumulative drug released was determined by UV spectrophotometer. FTIR studies revealed that drug and all excipients are compatible. The data obtained from in- vitro permeation studies was treated by various conventional mathematical models (zero order, first order, Higuchi and Korsmeyer- peppa’s) to determine the release mechanism from the designed self emulsifying formulations. Selection of a suitable release model was based on the values of R2 (correlation coefficient), k (release constant) obtained from the curve fitting of release data. It was found that all the formulations follows the first order kinetics. The regression coefficients for the all formulations F1 to F4 of Higuchi plot was found to be almost linear. Key words: SEDDS, ketaconazole, antifungal drug, topical drug delivery.

The colon is the terminal part of the GIT which has gained increased importance not just for the delivery of the drugs for both local and systemic administration. The delivery of drug for the treatment of local diseases associated with the colon like Crohn’s disease, ulcerative colitis, etc. but also for the systemic delivery of proteins, therapeutic peptides, anti-asthmatic drugs, antihypertensive drugs and anti-diabetic agents. To achieve successful colon targeted drug delivery, a drug need to be protected from degradation, release and absorption in the upper portion of the GI tract and then to be ensured abrupt or controlled release in the proximal colon and that system refers to delivery of drug in to lower part of the GI tract, mainly large intestine. When this is the most important delivery of those drug which are normally inactivated in the upper parts of the gastrointestinal tract (GIT). This review mainly compares the primary approaches for CDDS (Colon Specific Drug Delivery) namely prodrugs, pH and time dependent systems, and microbial triggered systems, which achieved limited success and had limitations as compared with newer CDDS namely pressure controlled colonic delivery capsules, CODESTM, and osmotic controlled drug delivery (ORDS-CT) which are unique in terms of achieving the in vivo site specificity, and feasibility of manufacturing process for the CDDS. These treatments could be more effective if it is possible for drug to be directly delivered to colon. This review article discusses introduction of colon, need and approaches of colonic drug delivery, factor effecting colonic transition, colonic diseases and the novel and emerging technologies for advanced colon targeting for site specific drug delivery to colon. It is a challenging area for future research and holds lots of promises for novel and efficient approach for targeted drug delivery system.