ketaconazole

The aim of present work was to develop a self emulsifying emulsion of ketaconazole for the topical delivery system which is useful in the treatment of fungal infection. Prepared SEDDS was investigated for different parameters. All the prepared SEDDS showed acceptable physical properties concerning colour, viscosity, melting point etc. The results of in -vitro drug release showed that carbopol 934 was the formula of choice as it showed better drug release & antifungal activity. The percentage cumulative drug released was determined by UV spectrophotometer. FTIR studies revealed that drug and all excipients are compatible. The data obtained from in- vitro permeation studies was treated by various conventional mathematical models (zero order, first order, Higuchi and Korsmeyer- peppa’s) to determine the release mechanism from the designed self emulsifying formulations. Selection of a suitable release model was based on the values of R2 (correlation coefficient), k (release constant) obtained from the curve fitting of release data. It was found that all the formulations follows the first order kinetics. The regression coefficients for the all formulations F1 to F4 of Higuchi plot was found to be almost linear. Key words: SEDDS, ketaconazole, antifungal drug, topical drug delivery.