paw oedema

Achyranthus aspera Linn, Moringa oleifera Lam and Scopharia dulcis Linn are used in the traditional system of medicine for the treatment of many diseases. Achyranthus aspera (AA) the whole plant and especially the roots, characterized by their uterine stimulant activity, are prescribed in the therapy of rheumatism, lumbago, osteodynia, dysuria, post-partum haematomata and dysmenorrhoea. There is no doubt that the pure Moringa oleifera (MO) Tree leaf is the source of incredible health benefits. It's the ultimate, natural, organic, energy and endurance health supplement. Scopharia dulcis (SD) plant has long held a place in herbal medicine in almost every tropical country where it grows, and it is much used by indigenous people. In this present work the flavonoid and phenolic content of the three plants were estimated. Then the  anti inflammatory activity of the plants were evaluated by Carrageenan induced   paw oedema method with alcoholic and aqueous extracts of the plants and the Analgesic activity was evaluated by Acetic Acid Induced Writhing Test Method. The plants are having very good significant effect in the Anti-inflammatory and Analgesic activity and it  may be due to the presence of flavonoids .

The present experimental research work was undertaken to determine the analgesic and anti-inflammatory activities of novel xylopia aethiopica formulations based on folklore methods used in Nigeria for the management of chronic severe painful conditions on eggwhite induced paw oedma in both sex of albino wistar rats using the pain models of Randall and Selitto (1957) as adopted by Ugo Basile (Italy). Analgesic and anti-inflammatory activities of the different analgesia models at doses as low as 0.5mg/ kg & 2mg/ kg respectively were evaluated against the standard analgesic drug Piroxicam, at dose of 20mg/ kg. The analgesic and anti-inflammatory activities was dose, and sex dependant: females appearing to endure more pains than males and in the ratio 2:1; suggesting that xylopia aethiopica is efficacious in ameliorating pains .The results from the study demonstrated strong anti- nociceptive than anti-inflammatory activities and as evidenced the bioactive constituents of hydro-alcoholic formulations, particularly, hydro-methanolic, potentiated the effects which resonated with the local use of finished products and practices for medicine purposes. Studies with the pure samples are on the way in order to understand the precise mechanisms of action. Key words: Analgesic & anti-inflammation activity, Piroxicam, xylopia aethiopica, hydro-alcoholic formulation, paw oedema, sex.