orally disintegrating tablet

Orally disintegrating tablet are gaining popularity over conventional tablets due to their convience in administration and suitability for patients. The purpose of the research was to mask the intensely bitter taste of tramadol hydrochloride and to prepare orally disintegrating tablets for achievement of quick onset of action of the drug. Tramadol hydrochloride is an analgesic which has been prove to be efficient in managing relief from pain and including pain after surgery. In the present study an attempt has been made to prepare bitter less orally disintegrating tablet of tramadol hydrochloride using Eudragit EPO as a taste masking agent. Direct compression method was used for preparing tablet & super disintegrating agent like Crosspovidone, Crosscarmellose sodium and sodium starch glycolate were used to prepare blend and evaluated for pre-compression parameter such as bulk density, compressibility, and angle of repose etc. the prepared batches of tablets were evaluated for hardness, weight variation, friability, drug content, disintegration time and in-vitro dissolution profile was found to be satisfactory. It was found that Eudragit EPO being hydrophilic facilitated the increase in the uptake of the saliva thus showing the complimentary action of that superdisintegrant.

The objective of the current study was to develop and optimize an orally disintegrating tablet formulation of Metoprolol tartrate which is an effective drug in the treatment of hypertension. Metoprolol tartrate orally disintegrating tablets were prepared by direct compression method using different ingredients such as Mannitol, Microcrystalline cellulose, Aspartame, Crospovidone, Sodium starch glycolate, Croscarmellose sodium, Powder flavours Strawberry, peppermint & orange, Colloidal silicon dioxide and Magnesium stearate. Tablets were evaluated for the physical properties, out of which disintegration time and wetting time were considered as responses in a 32 full factorial experimental plan. Results were statistically examined using design expert software and polynomial mathematical equations; found to be statistically significant (p