Tramadol hydrochloride

The aim of the present work was to design controlled release tablet of Tramadol hydrochloride for prolong release and it’s in vitro evaluation. Controlled tablets of Tramadol hydrochloride comprised HPMC K15M, and HPMC K100M as the release retarding polymers. These tablets were prepared by direct compression method. The seven different formulations (F1-F7) were evaluated for pre- and post-compression parameters. In vitro dissolution studies were carried out for the optimized formulation (F7). It has found that the release of drug from the sustained release layer by 99.5% in 12 h. FT-IR studies revealed that there was no interaction between the drug and polymers used in the study. The release of Tramadol hydrochloride was found to follow a pattern of Korsmeyer-Peppas, with Quasi-Fickian diffusion. Accelerated stability studies were carried out on the prepared tablets in accordance with ICH guidelines. There were no changes observed in physicochemical properties and drug release pattern of tablets. The controlled drug release pattern was successfully achieved through the formulation of controlled tablets in this study.

Orally disintegrating tablet are gaining popularity over conventional tablets due to their convience in administration and suitability for patients. The purpose of the research was to mask the intensely bitter taste of tramadol hydrochloride and to prepare orally disintegrating tablets for achievement of quick onset of action of the drug. Tramadol hydrochloride is an analgesic which has been prove to be efficient in managing relief from pain and including pain after surgery. In the present study an attempt has been made to prepare bitter less orally disintegrating tablet of tramadol hydrochloride using Eudragit EPO as a taste masking agent. Direct compression method was used for preparing tablet & super disintegrating agent like Crosspovidone, Crosscarmellose sodium and sodium starch glycolate were used to prepare blend and evaluated for pre-compression parameter such as bulk density, compressibility, and angle of repose etc. the prepared batches of tablets were evaluated for hardness, weight variation, friability, drug content, disintegration time and in-vitro dissolution profile was found to be satisfactory. It was found that Eudragit EPO being hydrophilic facilitated the increase in the uptake of the saliva thus showing the complimentary action of that superdisintegrant.