HPMC K100M

The aim of the present work was to design controlled release tablet of Tramadol hydrochloride for prolong release and it’s in vitro evaluation. Controlled tablets of Tramadol hydrochloride comprised HPMC K15M, and HPMC K100M as the release retarding polymers. These tablets were prepared by direct compression method. The seven different formulations (F1-F7) were evaluated for pre- and post-compression parameters. In vitro dissolution studies were carried out for the optimized formulation (F7). It has found that the release of drug from the sustained release layer by 99.5% in 12 h. FT-IR studies revealed that there was no interaction between the drug and polymers used in the study. The release of Tramadol hydrochloride was found to follow a pattern of Korsmeyer-Peppas, with Quasi-Fickian diffusion. Accelerated stability studies were carried out on the prepared tablets in accordance with ICH guidelines. There were no changes observed in physicochemical properties and drug release pattern of tablets. The controlled drug release pattern was successfully achieved through the formulation of controlled tablets in this study.

This  study was  focused over  the  designing  of sustained  release  HPMC  K100M  micropellet dosage form for  Ibuprofen which is an anti-inflammatory agent and broadly used for treating mild and severe pains. The approach of this study was to make a comparative evaluation among polymers  &  excipients  and  to  assess  the  effect  of  physicochemical  nature  of  the  active ingredients on the drug release profile. The prototype micropellets were obtained using drum pelletizer at 300 rpm. Percentage of water in binding liquid, i.e. IPA, is varied from 95 to 99% and  the effect  over  various parameters,  such as  particle size,  entrapment,  bulk  density and particle  shape,  were observed. Concerning the results of prototype preparation of Ibuprofen micropellets  were  prepared  using  HPMC  K100M,  as  release  retardant,  in  three  different concentrations i.e. 16.7%, 33.3% & 50%. Formulated micropellets showed particle size in the range of 275-284µm, bulk density (0.74-0.82 g/ml), % yield (25.9 -58.3%) & % entrapment (32.8-34.3%). Formulations showed the   maximum   desirability 0.996. Dry suspension formulation  parameters  such  as  pH  (5.15),  Viscosity  (450  cps),  Redispersibility  (5)  & Sedimentation volume (0.46 ml), was  found in  range. Formulation           PIH   were selected as the best   optimized  formulation  and  evaluated  for  In-vivo  parameters,  results  inferred  good sustainability with p>0.0001. Formulated micropellet showed sustained in-vitro dissolution rate, due to optimized polymer concentration. The micropellets were stable at 40°C±2°C/75%±5% RH as per ICH guidelines, after 3 months.

A controlled release system is designed to provide constant or nearly constant drug levels in plasma with reduced dose, frequency of administration and fluctuations in plasma concentrations via slow release over an extended period of time.One of the least complicated approaches to the manufacture of controlled release dosage forms involves the direct compression of blend of drug, retardant material and additives to formulate a tablet in which the drug is embedded in a matrix of the retardant. Gabapentin is an anti epileptic drug used for the treatment of epileptic seizures and in treatment of post therapeutic neuralgia.  In this study controlled released Gabapentin matrix tablets were prepared by using different matrix forming polymers which include hydrophilic polymers like HPMC K15M, HPMC K100M, Xanthan gum and hydrophobic polymer like Ethylcellulose in various ratios to retard the release of drug upto 12hrs. The formulations containing the combination of hydrophilic and hydrophobic polymer combinations (HPMC K100M with Ethycellulose) and the formulations prepared with the combination of two hydrophilic polymers of synthetic and natural origin (HPMC K100M with Xanthan Gum) exhibited maximum drug release(99%) upto12hrs during in vitro dissolution studies with optimum swelling characteristics.