in vitro drug release studies

The purpose of this research work was to formulate an anti-diabetic in a single dosage form i.e. Metformin HCl in sustained release layer and Miglitol in immediate release layer of the bilayer tablet. The tablets were prepared using Hydroxypropyl methylcellulose (HPMC K4M & HPMC K15M, sodium alginate and xantham gum) an as release retarding polymers in various combination and concentrations. The effect of different super disintegrants on immediate release in various concentrations was also studied. Eight formulations of immediate release layer were prepared using SSG and CCS super disintegrants with different proportions and were evaluated for different parameters. Among the eight formulations M4 containing CCS as disintegrant showed a better release of 95.50±0.15% for 30 mins was selected. Using this MT4 formulation eight formulations of sustained release layer of Metformin. HCL was prepared with HPMC k15M polymer and evaluated. Among nine formulations of bilayered tablets MM4 was showed 98.66±0.65% at the end of 8 hrs. was selected as optimized formulation.  This optimized formulation was evaluated for parameters like, thickness, hardness, friability, weight variation, drug content, in vitro   drug release and stability and results were found to be with in  USP limits.

Drug delivery via nanoparticle-based carriers has shown promising results for different types of diseases. Delivery of anti-gout agents into body is a mature line of investigation that has yet to realize its full potential. In this study we report on the development of a delivery platform for febuxostat. The work presented here describes the development of nanoparticles based on compritol. The method employed for the preparation of SLN is micro emulsification technique followed by high pressure homogenization. Phase diagram was developed to know the region of stable micro emulsion formation. Eight different formulas were developed with different concentrations of lipid, surfactant and aqueous concentrations. The developed formulations were evaluated for particle size distribution, zeta potential, entrapment efficiency, DSC thermal analysis and in vitro drug release studies. Among all the formulations developed, F3 formulation is showing better drug entrapment efficiency and controlled release of drug up to 24h. There was 12 fold increase in the solubility of drug in the developed formulation. The solid lipid nanoparticles of febuxostat can be prepared by using simple micro emulsification technique. The formulations had shown better release profile and solubility characteristics.