Croscarmellose sodium

The purpose of this research work was to formulate an anti-diabetic in a single dosage form i.e. Metformin HCl in sustained release layer and Miglitol in immediate release layer of the bilayer tablet. The tablets were prepared using Hydroxypropyl methylcellulose (HPMC K4M & HPMC K15M, sodium alginate and xantham gum) an as release retarding polymers in various combination and concentrations. The effect of different super disintegrants on immediate release in various concentrations was also studied. Eight formulations of immediate release layer were prepared using SSG and CCS super disintegrants with different proportions and were evaluated for different parameters. Among the eight formulations M4 containing CCS as disintegrant showed a better release of 95.50±0.15% for 30 mins was selected. Using this MT4 formulation eight formulations of sustained release layer of Metformin. HCL was prepared with HPMC k15M polymer and evaluated. Among nine formulations of bilayered tablets MM4 was showed 98.66±0.65% at the end of 8 hrs. was selected as optimized formulation.  This optimized formulation was evaluated for parameters like, thickness, hardness, friability, weight variation, drug content, in vitro   drug release and stability and results were found to be with in  USP limits.

In the present work Tadalafil fast disintegrating tablets were prepared with poloxamer as carrier to enhance the solubility of Tadalafil and in order to disperse at faster rate in the mouth. Chemically Tadalafil is (6R,12aR)-6-(1,3-Benzodioxol-yl) 2,3,6,7,12,12a hexahydro-2-methylpyrazino[10,20:1,6] pyrido [3,4-b]indole-1,4-dione used in erectile dysfunction. In this current work Tadalafil fast disintegrating tablets were formulated from F1-F12 by direct compression method by taking 1:1, 1:2 and 1:3 ratio of poloxamer as a water soluble polymer and super disintegrating agents such as crospovidine, croscarmellose sodium, sodium starch glycolate and kryon. There after FT-IR studies were performed and it was observed that there were no incompatible reactions found between the Tadalafil and excipients used in formulations. Then all the formulations of Tadalafil fast disintegrating tablets F1-F12 were evaluated for pre and post compressional parameters including in-vitro dissolution studies. In which formulation F-12, containing (1:3) ratio of drug-poloxamer and kryon as super disintegrating agent was shown significant changes in wetting time (13±2.09sec), dispersion time (36±3.605sec) and fastest percentage drug release of 99.27±2.78 within 30 minutes was observed.

Fast dissolving tablets are the tablet which dissolves rapidly and shows higher bioavailability than conventional tablets. The concept of formulating Fast dissolving tablets of Famotidine (H2 –receptor antagonist) offer suitable and practical approach in serving the desired objective of faster disintegration and dissolution characteristic with increase bioavailability and to know the effects of two synthetic superdisintegrant (Croscarmellose sodium and Sodium starch glycolate). In the present work two methods of solid dispersion were compared for improving the bioavailability i.e. Solvent Evaporation and Fusion method with PVP K30 as a carrier to increase the solubility of the drug. Comparison between these two synthetic superdisintegrant was done by taking different ratios and in combination. Three different combination of these superdisintegrant shows synergistic effect when it is compared to individual. Prepared tablets were subjected to different evaluation parameters such as hardness (2.84±0.15 kg/cm2 to 3.01±0.20 kg/cm2), friability (not more than 0.680±0.0173), weight variation (197.6±1.42 mg to 202.6±1.90 mg), drug content uniformity (97.84±0.35 to 100.23±0.71%), in vitro disintegration time (21.0±0.81 sec to 108.33±0.47 sec), wetting time (29.33±0.47 to 113.33±1.24 sec), in vitro dissolution studies and stability studies are carried out by using the best formulation. From all the formulations prepared and tested, F9 was found to the best formulation.

  Metoprolol Tartrate is effective β-blocker used in the second line treatment for angina and for myocardial infarction. Adult dose as conventional preparations is 25-100 mg daily in single or divided doses, as extended release 100-200 mg once daily. The bioavailability of the drug when formulated as conventional tablets is 40 % due to hepatic metabolism. The present investigation was undertaken with a view to develop a fast dissolving tablet of Metoprolol Tartrate which offers a new range of product having desired characteristics and intended benefits prepared by direct compression method using different concentrations of superdisintegrant. Effect of superdisintegrant on wetting time, drug content, in-vitro drug release, disintegration time has been studied. Disintegration time increased with increase in the level of Croscarmellose sodium while it decreased for Crospovidone, the release was dependent on the aggregate size in the dissolution medium. It is concluded that Metoprolol Tartrate fast dissolving tablets could be prepared using superdisintegrant with improved bioavailability and rapid onset of action.

  The task of developing immediate release tablet is accomplished by using a suitable diluents and super-disintegrants. Faster disintegration of the tablet administrated orally minimizes absorption time and improves its bioavailability in less time. Immediate Release tablet of Antibiotic drug is formulated using dry granulation using super disintegrant croscarmellose sodium. Azithromycin is Antibiotic drug is used to treat STDs due to Chlamydia and gonorrhea, community-acquired pneumonia, pelvic inflammatory disease, pediatric otitis media and pharyngitis, and Mycobacterium avium complex (MAC) in patients with advanced HIV disease. One of the important studies included in the present investigation is of study on process parameter effect on performance of the Immediate Release tablets. The effect of selected process parameters on critical properties of immediate release (IR) tablets were studied, like effect of disintegration time, friability, dissolution profile.   Key words: Immediate release, Azithromycin, Croscarmellose sodium