chalcone

Para hydroxyacetophenones react with different aldehydes of Para nitro benzaldehyde (Ia) ,Ortho nitro  benzaldehyde (Ib),4 hydroxy 3methoxy benzaldehyde (Ic) , 3, 4 dimethoxybenzaldehyde (Id)  in the presence of aqueous solution of potassium hydroxide and ethanol at room temperature to form 1,3 Diaryl-2-propane-1-ones or chalcones. The synthesized compounds were characterized by means of their IR spectral data. All the compounds were tested for their antibacterial activities by the cup plate method on E.coli ,Pseudomonasaeurgenosa, staphylococcus aeureous .Screening results shows that Id compound shows better antimicrobial activity against E.coli

Some chalcones (2a-2n) were synthesized by the condensation of various substituted benzaldehydes and unsubstituted/4-bromo acetophenone by using Claisen-Schmidt condensation. This is a comparative study of synthesizing compounds by conventional as well as non-conventional microwave irradiation in a commercially modified microwave oven. The research is focused on the remarkable reaction rate enhancement by the use of various non-conventional microwave irradiations which minimizes the time and solvents in reactions. Variety of functional groups such as nitro, chloro, dimethylamino, methoxy and methyl survived under the reaction conditions. The structures of newly synthesized compounds have been established on the basis of IR, 1H NMR spectral data and elemental analysis. The synthesized compounds were screened for analgesic and anti-inflammatory activity.