anti-oxidant

Spermacoce hispida possesses significant anti-oxidant and cardioprotective activities. This manuscript reveals the preventive potential of seed extract on lysosomal damage in isoproterenol induced myocardial infarction (MI) in rats. Two different doses of the plant extract such as 100 and 200 mg/kg body weight was used to prove the cardioprotective effect against 100mg/kg body weight of isoproterenol (ISO). The activities of lysosomal enzymes in the heart of ISO- induced MI rats were increased significantly.  Pretreatment with hydro alcoholic extract of seeds of Spermacoce hispida prevented the changes in the levels of lysosomal enzymes in isoproterenol induced MI rats. The activity of enzymes like β –D- Galactosidase, β –D- Glucuronidase, N-Acetyl β-D –glucoseaminidase, Cathepsin D and ATP ases are found to be increased in heart homogenate in diseased rats against normal animals.

Flavones, have been synthesized by the oxidative cyclization of 2'-hydroxychalcones using catalytic amount of iodine in presence of dimethyl sulfoxide (DMSO) in maximum yield. The synthesized compounds were evaluated for anti-oxidant and anti-inflammatory potential. Two compounds showed good anti-inflammatory activity as compared to their antioxidant activities. The synthesized compounds were characterized by IR, 1HNMR and MS Spectroscopy.

This investigation is made upon the plant Artocarpus chaplasha, the bark of it, to find out its anti-oxidant property. The anti-oxidant property of this plant part was investigated using different solvent for extraction, such as ethanol, ethyl acetate, methanol and chloroform. Different types extract is used to see different extent of result as many phytochemicals are readily extracted in ethanol but not in methanol, and so on. In case of anti-oxidant the scavenging power (IC50) of DPPH radical was 55.15, 163.10, 166.94 and 407.875µg/ml for aforementioned extracts respectively. By the time IC50 ascorbic acid has 47.19µg/ml. There’s also test for total phenolic and flavonoid content was carried out and the ressult for each was 3.63, 61.97, 2.15 and 3.18mg/gm for each extracts respectively in terms of phenolic content. Total flavonoid content was 116.17, 121.51, 82.33 and 63.67mg/gm for each different extracts respectively.