Therapeutics

Antimicrobial’s efficiency is critically compromised by the emergence and spread of antimicrobial resistance, yet they are valuable therapeutics. Investigations were carried to test and analyze the antimicrobial susceptibility of E. coli isolates from Ajmer poultry farm. 24 tissue samples containing 6 liver, 12 small intestine, and 6 large intestine samples were processed for isolation and identification and characterization of pathogenic E. coli from 12 fowls of 4 selected poultry farms of Ajmer suspected for colibacillosis and subjected to detailed bacteriological and biochemical examination. 24 E. coli isolates were isolated following standard procedures. E. coli isolates found to be highly resistant to some of the classical drugs like tetracycline, amoxy clav, carbenicillin, cotrimoxazole and cefopodoxime and found to be highly sensitive (100%) to the remaining drugs, which is disclosed by antibiogram study. The most ineffective antibiotic drug was found to be tetracycline for all the E. coli isolates, as all these microbes were found 100% resistant to it. Multiple resistance to at least 2 to 4 antibiotics were observed in all the 24 isolates. 50% of the isolates were resistant to at least 4 antibiotics and 75% to at least 3 antibiotics and 25% to at least 2 antibiotics. Results from this study revealed the high prevalence rate of multidrug resistant E. coli isolates. It may suggest that the high resistance of E. coli to antibiotics constitutes a threat not only to poultry industry of Ajmer but also possesses a serious threat to public and animal health with adverse economic implications.