Keyword
Serum protein binding
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Publications Tagged with "Serum protein binding"
1 publication found
2016
1 publicationQuantitative Structure-Pharmacokinetic Relationship (QSPkR) Analysis of the Serum Protein Binding Values for Antidiabetic Agents In Humans
Sethi Reeta and Paul Yash
4/1/2016
An estimate of Serum protein binding (%SPB) is of paramount importance in assessing the efficacy of drugs used to treat diabetes in patients. This study was conducted to develop Quantitative Structure Pharmacokinetic Relationship (QSPkR) for the prediction of %SPB in human for congeneric series of 23 antidiabetic drugs, using computer assisted Hansch approach. The QSPkR correlations were duly analyzed using a battery of apt statistical procedures and validated using leave-one-out (LOO) approach. Analysis of several hundreds of QSPkR correlations developed in this study revealed high degree of cross- validated coefficients (Q2) using LOO method (p
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Total Publications:1
Years Active:1
Latest Publication:2016
Contributing Authors:2
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