Quantitative Structure-Pharmacokinetic Relationship (QSPkR) Analysis of the Serum Protein Binding Values for Antidiabetic Agents In Humans

An estimate of Serum protein binding (%SPB) is of paramount importance in assessing the efficacy of drugs used to treat diabetes in patients.  This study was conducted to develop Quantitative Structure Pharmacokinetic Relationship (QSPkR) for the prediction of %SPB in human for congeneric series of 23 antidiabetic drugs, using computer assisted Hansch approach.  The QSPkR correlations were duly analyzed using a battery of apt statistical  procedures and validated using leave-one-out (LOO) approach. Analysis of several hundreds of QSPkR correlations developed in this study revealed high degree of cross- validated coefficients (Q2) using LOO method (p