Phytoconstituents

The evaluation of plant products on the basis of medicinal and therapeutic properties forms a platform for the discovery of newer drug molecules from different plant sources. To compare anti-diabetic effect between two ethanolic extracts of selected plants locally available in Bobbili region, Vizianagaram district, Andhra Pradesh, India on Streptozotocin induced diabetic rats. To compare anti-diabetic study, experimental rats were divided into five groups viz. Group I (Control), Group II (Diabetic, Streptozotocin, 50mg/kg bwt, i.p.), Group III (Diabetic with Glibenclamide(4mg/kg)), Group IV (Diabetic with Origanum majorana) and Group V (Diabetic with Indigofera linnaei Ali). Both plants extracts were supplemented with same dose i.e. 100mg/kg b.wt, orally. The blood glucose levels, lipid profile, body weight were evaluated in all above experimental groups before and after diabetes induction in 21 days pharmacological evaluation. Significantly decreased blood glucose level and simultaneously improved lipid profile and body weight in Group IV rats after oral administration of ethanol extract whereas in Group V rats are showing less effect compare to Group IV rats. Both the plant extracts effect compare with Group II and Group III rats statistically. Origanum majorana shows better antidiabetic activity because the leaf contain huge amount of antidiabetic phytoconstituents like rutin and quercetin flavonoids. In Indigofera linnaei Ali whole plant ethanol extract also shows antidiabetic activity because it contains kaempferol like important antidiabetic active constituents. Origanum majorana and Indigofera linnaei Ali plants may be used as a dietary supplement in diabetic patients. Further study is required to evaluate the antidiabetic activity.

Liver harm is most vital health issues or so a lot of than 900 medicines involved in case of liver injury. World health organization estimate that eightieth of total population used herbal drugs for some characteristic of primary health care while not any facet effects. Herbal medicine has emerged as a skilled approach with sensible values in handling various diseases, developing an affordable phytotherapy to treat severe liver diseases needs economical exploration of properties like antiviral action, antihepatotoxicity, stimulation of liver regeneration besides choleretic activity. The search used

Aegle marmelos, commonly known as Bael tree belonging to family Rutaceae is moderately sized, deciduous tree throught in dry forest hill of India & Central & Southern Asian countries. The different parts of plant contain numerous phytoconstituents like alkaloids, flavonoids, coumarins, essential oil etc. In this present study pharmacognostic evaluation is carried out which includes macroscopy, quantitative analysis & Phytochemical Screening. The various leaf extracts were subjected to preliminary phytochemical screening which will help in future for the standardization of formulation containing A.marmelos.