MCC

ABSTRACT: The aim of the present study is to design and evaluate the controlled release Glyburide trilayer matrix tablets, to achieve zero-order drug release for sustained plasma concentration. Matrix tablets were prepared by direct compression whereas three-layer tablets were prepared by compressing polymer barrier layers on both sides of the core containing the drug. Formulations were prepared by using different grades of hydroxy propyl methyl cellulose and Ethyl cellulose. Based on the evaluation parameters, drug dissolution profile and release drug kinetics HF16 was found to be optimized formulation. These results also demonstrated the suitability of three-layered tablet formulation of Glyburide to provide controlled release for prolonged period and improved linearity for Glyburide in comparison to marketed product in the management of Diabetes. Keywords: Glyburide, Type II Diabetes, HPMC Grades, EC, MCC, Release order kinetics.  

The aim of present research work is to formulate and evaluate Oral dispersible tablets of frovatriptan using various diluents and superdisintegrants and to optimize the formulation. Frovatriptan is a triptan drug  used for the treatment of migraine headaches. The drug excipient compatibility study was done and  no interactions were found, DSC & XRD studies were carried out. The tablets were formulated by direct compression method using Spray dried lactose, Manito, Microcrystalline cellulose (MCC), Starch as diluents and Crospovidone, Cross-Carmel lose sodium, Sodium starch glycol ate as superdisintegrants. The pre-compression parameters like bulk density, tapped density, Carr’s Index, Haunters ratio and angle of repose were determined and all the formulations were found to be within IP limits. The post compression parameters like the hardness, thickness, friability, weight variation, and disintegrating time, wetting time, water absorption ratio and drug content for all the formulations were carried out and results were found to be as per USP limits. In-vitro drug release and kinetics studies were carried out for all the formulations, of those the formulation F33 containing Cross providing (5%) and mannitol as diluent, has shown better release and follows first order kinetics. The formulations were optimized by 22 factorial design and the ANOVA study was carried out and normal plot, half normal plot and overlay plot were plotted. The tablets were stored at 40±2ËšC/75 ± 5% RH for three months to assess the stability of optimized formulation.

The present investigation is to Design and In-vitro evaluation of the sustained release matrix tablets of Glimepiride used for the treatment of type 2 diabetes mellitus. The Glimepiride (6mg) sustained-release (SR) matrix tablets were prepared by wet granulation method using different concentrations of hydrophilic and hydrophobic polymers. Such as Xanthumgum, Microcrystalline Cellulose, Povidone, Guargum, Magnesium Stearate, Pectin. The mechanism of action of glimepiride in lowering blood glucose appears to be dependent on stimulating the release of insulin from functioning pancreatic beta cells. The mixture of Glimipride powder was subjected to pre compression evaluation such as angle of repose, loose bulk density, tapped bulk density, hausarner’s ratio and compressibility index. The FTIR Spectrum is carried for the pure drug and for the optimized formula. This indicated that there was not any interaction between drug and polymer. All the formulations (F1-F12) were evaluated for weight variation, hardness, thickness, Friability, Content uniformity and invitro dissolution. The invitro dissolution studies were performed in pH 7.4 indicated that formulation F8 (Glimepiride and Guar gum in the ratio of 1:6) is the most success full formulation of this study and exhibited drug release 99.2% in 12 hr.  To investigate the drug-release kinetics, data were fitted to various kinetic models such as zero-order, first-order, Higuchi equation, Korsmeyer-Pappas equation, and Hixson–Crowell equation.

The main objective of present investigation is to formulate fast dissolving tablets of Diclofenac sodium and to evaluate flow, mechanical and release properties of diclofenac sodium tablets formulated by using two different super disintegrating agents namely sodium starch glycolate and microcrystalline cellulose. Two batches of formulations were prepared. F1 to F4 are formulated by using SSG with varying concentrations of 10 mg, 20 mg, 30 mg & 40 mg. similarly next four formulations (F5 to F8) were formulated by taking MCC as superdisintegrant with varying concentrations of 10 mg, 20 mg, 30 mg & 40 mg. All the eight formulations are having good flow properties and are prepared by direct compression technique.  Compatibility studies were conducted by using FTIR and all the excipients used in the formulation were compatible with the drug.  All the eight formulations shows first order release. The dissolution kinetics was presented in Table 5. The dissolution rate followed first-order kinetics as the graphs drawn between log % drug unreleased vs time were found to be linear. The dissolution rate of diclofenac sodium was found to be effected by the concentration of the superdisintegrant (sodium starch glycolate) used in the preparation of tablets. Based on the dissolution rate, the order of drug release from the four formulations was F4> F3> F2> F1. The formulation prepared with 40 mg of sodium starch glycolate (F4) was offered relatively rapid release of diclofenac sodium when compared with other concentrations employed in this investigation.