Direct compression method.

The Main goal of the present study was to develop and evaluate the orally disintegrating mini-tablets (ODMTs) containing Salbutamol sulphate for the treatment of respiratory disorders like Asthma and Chronic obstructive pulmonary diseases. The problems associated with conventional oral dosage forms are associated with slow down onset of action and lag time, while parenterals and aerosol despite of quick-outset of action strongly affect the patient compliance. Quick release tablets are highly accepted rapid increasing drug delivery systems and thus, an attempt was made to improve the onset of action of drug. To reach this goal, selective superdisintegrants like Crospovidone and Sodium starch glycolate were used in different ratios. Micromeritic properties of the powder were within the limit confirmed by free flowing. ODMTs were compressed in order to have sufficient mechanical strength and integrity to withstand handling, shipping and transportation. The tablets were prepared by direct compression method and physicochemical properties were evaluated. FTIR and DSC studies were confirms no chemical interaction between the excipients and drug. Out of six formulations prepared tablet F3 resulted a least dissolution and disintegration time. Hence, concluded that ODMTs give the better effect to the asthma patients and may serve as a successful strategy for enhancing the bioavailability of drug.

The main objective of present investigation is to formulate fast dissolving tablets of Diclofenac sodium and to evaluate flow, mechanical and release properties of diclofenac sodium tablets formulated by using two different super disintegrating agents namely sodium starch glycolate and microcrystalline cellulose. Two batches of formulations were prepared. F1 to F4 are formulated by using SSG with varying concentrations of 10 mg, 20 mg, 30 mg & 40 mg. similarly next four formulations (F5 to F8) were formulated by taking MCC as superdisintegrant with varying concentrations of 10 mg, 20 mg, 30 mg & 40 mg. All the eight formulations are having good flow properties and are prepared by direct compression technique.  Compatibility studies were conducted by using FTIR and all the excipients used in the formulation were compatible with the drug.  All the eight formulations shows first order release. The dissolution kinetics was presented in Table 5. The dissolution rate followed first-order kinetics as the graphs drawn between log % drug unreleased vs time were found to be linear. The dissolution rate of diclofenac sodium was found to be effected by the concentration of the superdisintegrant (sodium starch glycolate) used in the preparation of tablets. Based on the dissolution rate, the order of drug release from the four formulations was F4> F3> F2> F1. The formulation prepared with 40 mg of sodium starch glycolate (F4) was offered relatively rapid release of diclofenac sodium when compared with other concentrations employed in this investigation.