Fast dissolving tablet

The purpose of present research was to formulate and develop the patient friendly pantoprazole sodium fast dissolving tablets using sublimation method to achieve rapid dissolution. In this study, an attempt was made to fasten the drug release from the oral tablets by incorporating the superdisintegrants and camphor/ammonium bicarbonate as subliming agents. The prepared fast dissolving tablets were subjected to pre-compression analysis and evaluated for hardness, weight variation, friability, wetting time, water absorption ratio and disintegration time. From the results of in vitro drug release studies, the formulation F9 exhibited fast release profile of about 95.21% in 14 min and disintegration time 90 sec when compared with other formulations. For the optimized formulation F9, the initial dissolution rate was 38.82% / 2 min. Fourier transform infrared spectroscopy studies revealed that there was no possibility of interactions between drug and excipients. The present study demonstrated potential for rapid absorption, improved bioavailability, effective therapy and patient compliance.

  Rhinitis may be of allergic and non allergic origin and the reaction was typically associated to the nasal and ocular symptoms of the disease, allergic rhinitis was associated with a higher burden of asthma and sinusitis. It also affects multiple areas related to quality of life. Due to these reasons, there is a need to develop rapid action producing formulation to treat these allergic conditions. Levocetrizine is the active enantiomer of cetirizine. It is second generation, non-sedative antihistaminic drug with half-life of 8-10 hrs.The usual dose range from 5 to 10 mg. It undergoes extensive metabolism. The objective of the current study was to develop and optimize fast dissolving tablet of levocetrizine hydrochloride to improve bioavailability and increase drug release with rapid onset action. Key word: Fast dissolving tablet, Superdisintegrant, Rapid action, Patient compliance

The main objective of this study was to formulate and evaluate the fast dissolving tablets of Gliclazide with natural superdisintegrants. Various formulations were prepared by direct compression using different concentrations of natural superdisintegrant i.e. isolated mucilage of Plantago ovata, isolated mucilage of Aloe vera and extracted mucilage of Hibiscus rosasinesis. The initial compatibility studies between the drug and excipients were carried out using FTIR spectroscopy. The blend was evaluated for additive properties. The tablets were evaluated for physical parameters and in vitro drug release. The disintegration time and in vitro drug release of optimized formulation (P4) was found to be 2.41±0.05 secs. The optimized formulation was subjected to stability studies for three months. The formulation was found to be stable, with insignificant change in the hardness, disintegration time, drug content and in vitro drug release pattern.

  Piroxicam is a non-steroidal anti-inflammatory drug, classified in the Biopharmaceutics Drug Classification system as a Class II drug with low solubility and high permeability. It demonstrates a slow and gradual absorption via the oral route and has a long half-life of elimination, rendering a prolonged therapeutic action and a delayed onset of anti-inflammatory and analgesic effect. The basic objective of the present study is to formulate and evaluate the fast dissolving tablet of Piroxicam. Study proposes the use of a Sodium Satrch Glycolate (SSG) alone to prepare solid dispersion of piroxicam and comparison of its in-vitro dissolution with pure piroxicam. Fast Dissolving tablets can be prepared by conventional direct compression method using solid dispersion of superdisintegrants which shows rapid rate of disintegration. For better Hardness, less friability, faster wetting time and less moisture uptake combination of both MCC and Mannitol are required in the formulation.   Key Words: Fast dissolving tablet, Piroxicam, Sodium starch Glycolate (SSG)