Formulation and Optimization of Fast Dissolving Tablet of Levocetrizine Hydrochloride

  Rhinitis may be of allergic and non allergic origin and the reaction was typically associated to the nasal and ocular symptoms of the disease, allergic rhinitis was associated with a higher burden of asthma and sinusitis. It also affects multiple areas related to quality of life. Due to these reasons, there is a need to develop rapid action producing formulation to treat these allergic conditions. Levocetrizine is the active enantiomer of cetirizine. It is second generation, non-sedative antihistaminic drug with half-life of 8-10 hrs.The usual dose range from 5 to 10 mg. It undergoes extensive metabolism. The objective of the current study was to develop and optimize fast dissolving tablet of levocetrizine hydrochloride to improve bioavailability and increase drug release with rapid onset action. Key word: Fast dissolving tablet, Superdisintegrant, Rapid action, Patient compliance