Anticonvulsant

New Chemical Entities (NCEs) were designed using information from pharmacophore profile of known anticonvulsants. Binding affinities of designed NCEs were studied on gamma-aminobutyric acid (GABA-alpha) using docking studies. Two Dimensional (2D) Quantitative Structure–Activity Relationship (QSAR) studies were performed for correlating the chemical composition of triazolethione analogs and estimation of their anticonvulsant activity using Multiple Linear Regression (MLR) Analysis.  ADMET properties were also predicted. These four basic strategies (pharmacophore mapping, QSAR, docking & ADMET screening) were implemented to evaluate the performance of derivatives. Although predicted Ki through QSAR model showed significant mild activity for GABA. Conclusively compounds, 2, 6, 7, 8, 9, 10, 11, and 20 were observed to be most feasible to activate GABA for anticonvulsant activity.

Isatin is an endogeneous and an important class of heterocyclic compound. It possess indole nucleus having both keto and lactam moiety with a diverse pharmacological properties like antimicrobial, antitubercular, anticonvulsant activity etc. Isatin derivatives are synthetically important substrates, which can be used for the synthesis of a large variety of heterocyclic compounds, and as raw material for drug synthesis. Recently, isatin derivatives have attracted strong interest in organic and medicinal chemistry due to their potent biological and pharmacological activities. The purpose of this review is to provide information on the pharmacological activities of isatin and its derivative.