Antibacterial

Mannich bases of sparfloxacin were synthesized from the reaction of 5-acetylamino-1-cyclopropyl-7-(3΄,5΄-dimethyl-piperazin-1-yl)-6,8-difluoro-4-oxo1,4-dihydro-quinoline-3-carboxylic acid with formaldehyde and several isatin derivatives. The structures of the synthesized compounds were elucidated from the IR, 1H NMR, 13C NMR and FAB Mass data. The synthesized compounds were evaluated for the antibacterial, antitubercular and anticancer activity. The compounds showed good activity against Gram-positive bacteria and moderate activity against tested Gram-negative bacteria. The MIC for the compounds against M. tuberculosis H37Rv strain was 50 µg/mL. The most potent compound in this series 3c exhibited enhanced antibacterial activity than sparfloxacin against S. aureus, Bacillus Sp while the anticancer activity was in the range of 18.31- 23.61 µg/mL.

A series of [6-(p-substituted aminophenyl)-4-(p-substituted phenyl)—6H-1,3 thiazin-yl]-acetamides were synthesized via Claisen-Schmidt condensation. The titled compounds were characterized by IR, NMR analysis. The synthesized compounds were screened for their antibacterial and antifungal activity disc diffusion method. Among the synthesized compounds, T-2 was found to have a strong antibacterial and antifungal activity. Compounds T-1, T-3, T-4 and T-5 were found to have promising antimicrobial activity.

Cinnamon is the dried inner bark of stems of Cinnamomum zeylanicum belonging to the family Lauraceae. It is extensively used as spice since centuries worldwide. Apart from this it has been widely used for different medicinal purposes in Unani as well as Ayurveda system of medicine. Its trees are widely distributed throughout Sri Lanka, south-western India and Burma. It has been used in traditional systems of medicine for the treatment of various diseases like epilepsy, hemiplegia, chronic bronchitis, asthma, jaundice, skin and gastrointestinal disorders etc. The qualitative phytochemical analysis of the plant extracts shows the presence of essential oils, tannins and mucilage. Recent pharmacological and clinical studies revealed its antibacterial, antifungal, antitumour, immunomodulatory, wound healing and anti-inflammatory activities. This review is an effort to summarize the detailed prospects of ancient literature on C. zeylanicum along with modern researches.

  The present study aimed at evaluating the in vitro antimicrobial activity of various extracts of the stem bark of Bauhinia variegata Linn. In the current study, the petroleum ether, chloroform, ethyl acetate, ethanol and aqueous extract of stem bark of B. variegata L. was tested against standard bacterial and fungal cultures. The test was performed by agar well diffusion method on nutrient agar media and Sabouraud’s dextrose media for bacterial and fungal cultures respectively. Among the solvent extracts, ethanolic extract was effective against all the tested bacteria and fungi. Ethanolic extract exhibited maximum inhibitory activity against Klebsiella. And the least activity was observed for Staphylococus aureus. For fungi ethanolic extract was more effective against Aspergillus fumigates. Key words: Antibacterial, Antifungal, Bauhinia variegata L.