Anti-diabetic

Syzygium genus contain several plant species which spread across the world, most of them are having diverse biological activity among which some are reported, and some are not. So, Syzygium genus is a subject of interest to researchers. All Syzygium species are actively studied to find new activity or better dose at which they can be used. This review focuses on various species of genus Syzygium, their phytochemical constituents and their pharmacological activities. Syzygium aromaticum (Clove), Syzygium samarangense (Java apple), Syzygium anisatum (Aniseed tree), Syzygium caryophyllatum (Lilly pilly), Syzygium aqeum (Water apple), Syzygium jambos (Mountain Apple), Syzygium cumini (Java plum), Syzygium australe (Brush cherry), Syzygium luehmannii (Riberry) etc., were mentioned in this review article. Biological activities like anti-diabetic, antioxidant, anti-bacterial, anti-inflammatory, platelet inhibition, hepato-protective were found among plants of Syzygium species. Our present review mentions all the activities, anti-diabetic in detail. We tried to gather cumulative data as per our knowledge, hope it is useful to anyone who is studying or researching about Syzygium. Syzygium cumini is given importance in this review article as it has diverse uses and most of the parts of the plant have their own applications in medical field.

The anti-diabetic effect of aqueous and ethanol extract of leaves of Eugenia operculata Roxb. was evaluated in streptozotocin induced diabetic mice. Streptozotocin is a synthetic nitrosoureido glucopyranose derivative isolated from fermentations of Streptomyces acromogenes. STZ induced diabetes by selectively destroying the insulin producing β cells by inducing necrosis. Extract (250mg/kg b.w) was administered orally to albino mice both normal and diabetic for 21 days. The anti-diabetic potential was assessed by determining oral glucose tolerance, fasting blood glucose, urine glucose, change in body weight, liver glycogen content and serum lipid profile. In oral glucose tolerance test, reduction of fasting blood glucose level was observed after 60 minutes of extract and standard administration. At the end of experiment maximum reduction of blood glucose level was seen significantly (p