Anti-diabetic activity of Eugenia Operculata roxb. In streptozotocin induced diabetic mice

The anti-diabetic effect of aqueous and ethanol extract of leaves of Eugenia operculata Roxb. was evaluated in streptozotocin induced diabetic mice. Streptozotocin is a synthetic nitrosoureido glucopyranose derivative isolated from fermentations of Streptomyces acromogenes. STZ induced diabetes by selectively destroying the insulin producing β cells by inducing necrosis. Extract (250mg/kg b.w) was administered orally to albino mice both normal and diabetic for 21 days. The anti-diabetic potential was assessed by determining oral glucose tolerance, fasting blood glucose, urine glucose, change in body weight, liver glycogen content and serum lipid profile. In oral glucose tolerance test, reduction of fasting blood glucose level was observed after 60 minutes of extract and standard administration. At the end of experiment maximum reduction of blood glucose level was seen significantly (p