Anthelmintic

Medicinal herbs as potential source of therapeutics have marked a crucial role in health system globally for both humans and animals. These are not only beneficial in the diseased condition but also used as potential material for maintaining proper health. The present study highlights the pharmacognostic studies on roots like powder microscopy and anthelmintic activity of different extracts on Indian adult earthworms. Different concentrations (50-150 mg/ml) of plant extract were tested in this study. Albendazole (20 mg/ml) was used as reference standard drug whereas CMC as control. Determination of paralysis time and death time of the worms were recorded. Extract exhibited significant vermicide activity in dose dependent manner. The result shows that methanolic extract possesses anthelmintic activity and found to be effective as an anthelmintic.

Present generation is a fast moving generation and no doubt about the potency of allopathic medicine, they provide fast result, but the darkest side of this medicine is their several side effects and contraindications. On the other hand the Ayurvedic medicines are good substitution for those medicines because of their less or no side effect and their ability to cure the problem from their root. The present study is based on the pharmacological activity of Dhanwantari’s Ditoxifie capsule. This drug is having great potential to deal with ache of muscles or joints, frequent headaches, low energy or frequent being tired, frequent cold or sickness, coughs or a sore throat, runny nose or sinus congestion, dense or yellow urine, painful bowel movements, acne or oily skin, lack of taste and many more. In the present work, experiments were conducted to evaluate the possible anthelmintic effects of Ditoxifie capsule on Indian earthworm (Pheretima posthuma) at 400mg/ml, 600mg/ml, and 800mg/ml concentration. Results were expressed in terms of time for paralysis and time for death of worms.

The present study describes screening for antimicrobial and anthelmintic activity of the petroleum ether and alcoholic extracts of Corchorus depressus Linn. (Tiliaceae). The plant has been used in the traditional Indian system of medicine as an antibacterial, antifungal and anthelmintic drug, as a tonic, cooling medicine in fevers; its mucilage is prescribed in gonorrhea. Root is rubbed on stone and smeared over forehead to get relief in migraine; extract of plant is applied as a paste in healing of wounds. The HPLC chromatograms of the methanolic extract shows a single large peak with a retention time 6.451 min along with other components.  The Anthelmintic activity was studied on adult Indian earthworms, ‘Pheretima posithuma’. The methanolic extract produced more significant Anthelmintic activity than petroleum ether extract and the activities are comparable with the reference drug Piperazine citrate. The methanolic whole plant extract exhibited significant anti bacterial, antifungal activity, comparable to the standard drug tetracycline. The present study confirms the folklore claim of the plant utilized for its antimicrobial activity

The present work deals with the synthesis of azetidinone derivatives of quinazolinones and  the structures of the compounds obtained have been established based on spectral (IR, 1H NMR,13C NMR and Mass) data. The present study also involves in vitro anthelmintic and antibacterial activity of the synthesized derivatives a few strains (gram positive and gram negative) of bacteria. All the compounds showed against moderate to satisfactory activities.

Modern synthetic medicines are highly effective in curing various diseases, but many of them show significant side effects. A large number of Indian herbs are claimed to possess anthelmintic properties. However, systematic study and standardization of activities are lacking. The present investigations are undertaken to evaluate and standardize anthelmintic activities of common Indian herbs. Aqueous and ethanolic extracts of Plumbago zeylanica, Myristica fragrance and Saraca asoca are studied with respect to in vitro anthelmintic activity against Eisenia foetida and Pheretima posthuma. Results are expressed in terms of time for paralysis and time for death. Albendazole (20mg/ml) is used as a reference standard. Ethanolic extract of Saraca asoca (50 mg/ml) proved to be the best death inducer against Eisenia foetida, whereas ethanolic extract of Plumbago zeylanica at concentration 50mg/ml showed highest anthelmintic activity against Pheretima posthuma.

The plant Butea monosperma is a medium sized deciduous tree Belongs to family “Fabaceae” is called as “Dhak & Palas” in Hindi. This plant is used as Anti-inflammatory agent, Healing Power and Curative Properties, Diarrhoea and Dysentery, Skin Disorders, Diabetes, Leucorrhoea, Sore Throat Retention of Urine and Used as dye. In present study methanolic extract of plant is used for its anthelimintic property. The Anthelimintic activity was evaluated on adult Indian Earth worms (pheretima posthuma). Albendazole suspension was used as standard and antheliminitc potential of plant extract was evaluavated at three different concentrations. And found that methanolic extract of plant Butea monosperma contain significant and dose dependent antheliminitc activity.