Tanveer

Asthma is a complex, chronic inflammatory disease of the lower airways characterized by variable airflow obstruction and airway hyper-responsiveness. Inflammation has a central role in pathophysiology of asthma. Airway inflammation involves an interaction of many cell types and multiple mediators with the airways that eventually results in the characteristic pathophysiological features of the disease. Patients typically present with intermittent symptoms of cough, wheeze, dyspnea, and/or chest discomfort. Asthma is often associated with a history of atopy, and this association in asymptomatic patient is one of the most strongest predictors of asthma.

The aim of the present study is to enhance solubility of simvastatin by solid dispersion technique. Solid dispersions were prepared by fusion method by using various polymers. Formulation is optimized on the basis of acceptable solid dispersion properties and in-vitro release. In order to obtained best optimized product, 5 different formulations were developed. Different polymers like PEG 6000, HPMC 6000,HPC 1000 were taken as variables. Angle of repose, carr’s index, particle size, drug content and dissolution study were studied as response variables. The different physical properties showed best comparable results with drug. But higher percentage of drug release was observed when the formulation contained PEG6000 in 1:1.5 ratio (f5) compared to other formulations. Form this study it concluded that formulation (f5) which contained PEG (1:1.5) as polymer showed best dissolution profile compared to the drug. The formulation contained PEG 6000 was selected as optimized product.

There is an increasing incidence of cancer not just in our country but worldwide. The aim of this study is to evaluate socio-demographic data, knowledge, awareness, practice level in cancer patients through assessment of their respective attendants. A self-administered, structured, open ended and pretested questionnaire covering the general characteristics, KAP about cancer, screening and treatments was used to collect responses of cancer patient attendants in KIMS a Teaching Hospital at Hyderabad. Their age group was between 18-79years. The educational preparations of the attendants are as follows: 50 attendants are grouped as “CONTROL”, 50 are grouped as “TEST”. The information thus collected was entered and analyzed in SPSS and Microsoft Excel software. Responses from 100 attendants were recorded and analyzed. The results of both groups i.e. TEST and CONTROL pre-post interventions were tabulated and compared between the groups, educational intervention was given to only test group thus paired t-test results obtained at level of significance 0.005, shown that only test group attendants shown significant difference in aspects of knowledge and practice when compared to that of the control group who received information only at the end of the study. Our study has shown that educational interventional study give high scope in comparative studies where pre-post interventions were in use.

Melasma is a cosmetic problem that sometimes cause great emotional suffering. One survey showed that melasma was associated with a significant impact on health related quality of life. It is defined as a disorder of pigment metabolism characterized by sharply demarcated, blotchy, brown maculae, usually symmetrical on the cheeks, forehead, sometimes on the upper lip and neck. In Unani Medicine, it is mentioned that Kalf is due to black bile homour and charred blood parts, which oozes out of capillaries and get accumulated under the skin. The present study was a Randomized, parallel group, comparative clinical trial. The present research was done to evaluate and to compare the clinical efficacy of a topical application made up of powdered cuttlefish bone and lemon juice along with oral Cascuta reflexa capsule which was compared with another group that is oral placebo with same topical application. The efficacy of the treatment was evaluated by MASI, skin color shades chart, Patient’s Global Assessment,  Patient’s Satisfaction Index and DLQI. Assessment of safety was done by clinical assessment, patients’ complains about any adverse effects i.e. itching, inflammation, rashes, eruptions etc., DLQI and laboratory parameters such as LFT, KFT, CBC and Hb%. At the end of the treatment all the efficacy parameters showed significant improvement when compared with baseline in both the groups; however the difference between the groups was not statistically significant. Thus, topical application had promising effects in melasma. Key words- Kalf, Unani formulation, hyper pigmentation, MASI, cuttlefish bone 

A reaction between Moxifloxacin HCl and FeCl3 solution in slightly acidic medium was studied. It gave brown colour complex having maximum absorbance at 407.0nm. The reaction is selective for Moxifloxacin HCl with 0.00024µg/uL and different concentration of FeCl3 was applied.  The color reaction obeyed Beer’s law from 0.01 µg /µL to 0.00018 µg/µL of FeCl3 solution having concentration 0.1ug∕uL and relative standard deviation 0.026%.The quantitative estimation of moxifloxacin HCl in blood sample is also studied. Key Words: Moxifloxacin, UV-Visible Spectrophotometer, Ferric Chloride, Beer’s law, Color reaction, Analytical method

Peucedanum grande has been found to be associated with the multiple therapeutic properties. In the present study, we have used P. grande as an ameliorating agent against nephrotoxic effects of Mercuric chloride (HgCl2). The rats were given pretreatment of P. grande orally at a dose of 60 and 120 mg/kg body weight for five consecutive days. Mercury chloride 4 mg/kg body .wt was used as renal toxicant, and injected subcutaneously in the neck region in a volume of 1 ml/kg. The modulatory effects of P. grande on HgCl2 induced nephrotoxicity was investigated by assaying oxidative stress biomarkers, lipid peroxidation, serum kidney toxicity markers and by histopathological examination of kidney. The HgCl2 induced nephrotoxicity by depleting antioxidant levels, elevating the level of serum creatinine and BUN, as well as damaging the normal architecture of kidney. P. grande pretreatment prevented deteriorative effects induced by HgCl2 through a protective mechanism that involved reduction of increased oxidative stress as well as by restoration of histopathological change against HgCl2 administration.