Suriyavathana M

The aim of the present study was to evaluate the effect of Chromolaena odorata (C.odorata) and Boerhavia erecta (B.erecta) on lipid peroxidation and antioxidants in Lead acetate-induced Nephrotoxicity in male Wistar rats. The rats of the nephrotoxicity control group 2 were administered lead-acetate 10mg/kg body weight, intraperitoneally in 3 days once for 15 days. In nephrotoxicity rats, Oral treatment with C.odorata, B.erecta at a daily dose of (500 mg/kg b.wt) and silymarin (25 mg/kg b.wt) groups (3, 4 and 5) for last 15 days. The Lead-acetate-induced rats showed increase in the level of lipid peroxidation and decreased levels of superoxide dismutase, catalase, glutathione peroxidase and reduced glutathione in serum and kidney. Oral treatment with C.odorata, B.erecta and silymarin in nephrotoxicity induced rats showed significantly decrease in the levels of kidney and serum lipid peroxidation and significant (p

In India, many indigenous plants are used in herbal medicine to cure diseases and heal injuries. Major pharmaceutical companies are currently conducting extensive research on plant materials gathered from the rain forests and other places for their potential medicinal value. Toddalia asiatica (L.) Lam. (Rutaceae) is widely used as a folk medicine in India. The roots are used in the treatment of indigestion and influenza and the leaves to treat lung diseases and rheumatism. The root and its bark have been used to treat fever, malaria, cholera, diarrhoea and rheumatism 1. Despite the use of this plant for such purposes, there is little information on the biochemical composition of Toddalia asiatica.  L.Var . floribunda.. This work is therefore aimed at documenting the biochemical compositions of Toddalia asiatica. L. Var . floribunda. From the earlier reports qualitative phytochemical results reveals that the methanolic stem extract of Toddalia asiatica.L. contain secondary metabolites like  Alkaloids, Flavonoids, Saponins, Steroids, Glycosides, Tannins. From the quantification result of various biochemical and phytochemical constituents like carbohydrates, proteins, total ascorbic acid, phenols, tannins and flavanoids content, it was noted that alkaloid found to be the highest with phenol as the next active constituents among the secondary metabolites in the stem. From the results it reveals Toddalia asiatica has the potential to be represented as an effective biochemical and therapeutic constituent for the future use in the medical field.