S. Raja

This research aimed to evaluate a new approach for preparation of in situ gel and to design innovative peroral delivery systems for Ranitidine Hydrochloride (RHCl) able to enhance the control release. The present study was carried out to optimize and evaluate an oral in-situ gel containing ranitidine HCl with Pluronic F-127 and hydrophilic HPMC E50 by the simple mixing method. The compatibility of the polymers was proved by FTIR. The prepared in-situ gel formulations were tested for their physicochemical characteristics such as clarity, gel strength, gelation temperature, drug content, sol-gel transition time and in vitro release studies of ranitidine HCl-loaded in-situ gel formulation in phosphate buffer (pH 1.2 and 7.4. ) were performed using a modified diffusion cell across dialysis membrane. The prepared formulations were clear and Gel strength ranges from 31±1.6 to 33±1.2. The drug content for the prepared formulations was 97.23% to 99.02%.Then the Drug release at 12 h is 98.25 and thus shown controlled release.

Ixora pavetta Andrews, (var.: I. Parviflora Vahl.) is a small tree or evergreen shrub belongs to the family Rubiaceae, and is used for many ailments, especially for the treatment of to treat chronic wounds, urinary diseases, skin infection, pulmonary troubles, liver disorder, hair tonic, sedative, diuretic, diarrhoea, dysentery, leucorrhoea and veneral diseases. Preliminary phytochemical screening of ethanol exract of I. pavetta leaf showed the presence of alkaloids, flavonoids, tannins and saponin glycoside. In the analgesic activity, ethanol extract provoked a significant reduction of the number of writhes in acetic acid-induced writhing response, also significantly reduced the licking time in both phases of the formalin test and highest analgesia in hot-plate test (P < 0.01) compared to the control group. The anti-inflammatory effects were investigated employing the both carrageenan and arachidonic acid -induced hind-paw oedema in rats and results of the study revealed the extract to have significant (P

The Losartan Potassium buccal tablets have been developed as controlled drug delivery systems to improve the efficacy of Losartan Potassium through mucosal absorption, reduce dose frequency, toxicity, to improve bioavailability and patient compliance. Many processing variables can persuade the characteristics of the Losartan Potassium buccal tablets. The aim of the study was to study the effect of some selected process variables in the concentration of drug/locust bean gum, hydroxy propyl methyl cellulose K4M on the hardness, mucoadhesive strength and in-vitro release at different hours by applying central composite design, accounting the above independent variables. The central composite design with an R2 value of 0.9695, 0.9928, 0.5839, and 0.7556 has selected as a suitable model for further analysis. The model F value of 44.52, 277.61, 7.02, 15.46 with probability P>F

Acid-related disorders, including gastro esophageal reflux disease (GERD), duodenal ulcers, and gastric ulcers, are managed by H2 receptor antagonists and proton pump inhibitors (PPIs). PPIs represent first choice for treating acid-peptic ulcers inhibits the gastric- H+/ K+ -ATPase through covalent binding to cysteine residues of the proton pump. Achlorhydria and acute renal failure are the most common drawbacks. A reversible acid pump antagonist (APAs), currently in clinical trial removes these problems. The APAs are the conceivable future drugs for the treatment of acid-peptic disorders.