Mitesh P. Sonawane

Oral drug delivery systems most preferred option of administration for various drugs. Sustained release drug delivery system is the novel drug delivery system. The terms Sustained release, prolonged release, modified release, extended release or depot formulation are used to identified drug delivery systems that are designed to achieve or extend therapeutic effect by continuously releasing medication over an extended period of time after administration of a single dose. Sustained release dosage forms are designed to release a drug at a predetermined rate by maintaining a constant drug level for a specific period of time with minimum side effects. The basic rationale of sustained release drug delivery system optimizes the biopharmaceutical, pharmacokinetics, and pharmacodynamic properties of a drug in such a way that it’s utility is maximized, side effects are reduced and cure of the disease condition is achieved. Sustained release drug delivery is improved patient compliance due to less frequent drug administration, reduction of fluctuation in steady-state drug levels, maximum utilization of the of the drug, improved therapy and shorter treatment period.

Valacyclovir hydrochloride  is widely used for the treatment on Herpes virus, illness caused by Herpes virus such as Genital herpes, Cold sores, Chingles and Chicken pox. The present study is deals with formulation, optimization, evaluation of Valcyclovir HCL mouth dissolving films. Genital herpes, Cold sores, Chingles and Chicken pox are the conditions where instance effect of drug is required. Valacyclovir hydrochloride is one of the drug which is used in the treatment of above three disease conditions. The mouth dissolving films was prepared by using solvent casting method. The concentration of propylene glycol, sodium lauryl sulphate (SLS) were kept constant in all formulations (F1-F4) and varying concentration of hydroxy propyl methyl cellulose(HPMC) and methyl cellulose. All the formulations were evaluated for surface pH, weight uniformity, folding endurance, drug content, disintegration time, in-vitro dissolution studies. The formulation ‘F3’ was found to be optimized formulation. It shows results for all evaluation parameters such as weight variation 34.70±0.7mg, surface pH 6.75±0.60, folding endurance > 100, drug content 95.25±1.10%, disintegration time 30±0.50 sec, and in-vitro dissolution study 81.35±1.30 % at the end of 5 min.