Mahendra Singh

In the modern world, a number of heterocycles have emerged and are showing important roles in a variety of human-beneficial pharmaceutical compounds. Pyrazoles are nitrogen-containing heterocyclic compounds with five members. They have garnered a lot of attention because they belong to a significant class of chemicals for therapeutic development and Quinolines, A typical example of bicyclic heterocyclic compounds. Meanwhile, derivatives of pyrazole and quinoline have been synthesized as target structures and have shown a wide range of biological actions, including antitubercular, anticancer, antifungal, anti-inflammatory, antibacterial, and anti-tuberculosis properties. The findings of published studies on the synthesis and biological activity of quinoline and pyrazole derivatives are compiled in this review. The Scopus database was consulted to gather and evaluate the published research papers on the biological activities and synthesis of pyrazole and quinoline derivatives that were published between January 2019 and December 2023.

The wide occurrence of benzo fused and heterocyclic fused [1,4] oxazines in bioactive natural product and pharmaceuticals have made them important synthetic targets. 2H-1,4-pyridoxazin-3-(4H)-one   has been studied intensively as important heterocyclic systems for building natural and designed synthetic compounds. They are utilized as suitable skeletons for the design of biologically active compounds, ranging from anti-inflammatory, analgesics, bacteriostatic, fungistatic and MAO inhibitors etc. Various researchers with help of organic and analytical chemistry developed 2H-1,4-pyridoxazin-3-(4H)-one using different synthetic route.

  Fast dissolving, fast melting, chewable and orally dissolving or disintegrating tablets are solid dosage forms that disintegrate rapidly and dissolve in the mouth withoutwater. The principle challenge with orally disintegrating tablets (ODTs) is to develop tablet formulations for standard direct compression processes that deliver rapid disintegration, pleasant mouth feel and high breaking force for tablet robustness. Superdisintegrant affect a range of formulation parameters, including the rate of disintegration, tablet breaking force, and mouth feel. The emphasis on the availability of drug highlights the importance of the relatively rapid disintegration of a tablet as a criterion for ensuring uninhibited drug dissolution behavior. Number of factors affects the disintegration behavior of tablets. The development of fast dissolving or disintegrating tablets provides an opportunity to take an account of tablet disintegrants. Superdisintegrants are generally used at a low level in the solid dosage form, typically 1 – 10 % by weight relative to the total weight of the dosage unit. Key words: Tablet Disintegrants, Superdisintegrants, Kyron T-314.