Indira. M. Madawali

Benzimidazole is the heterocyclic compound which contains a phenyl ring fused to an imidazole ring, Benzimidazole analogs are of crucial importance because of their different clinical applications and biological activity. Benzimidazoles are known as an optimistic class of bioactive heterocyclic compounds possessing a wide variety of biological activities. Benzimidazole derivatives play an important role in medical field with so many pharmacological activities such as antimicrobial, antiviral, anticancer activity, antioxidant, antiparasitic, antiproliferative, antitumor, anti-HIV, anticonvulsant, antiprotozoal, analgesic and anti-inflammatory, antihypertensive, anticancer, androgen receptor antagonist, vasorelaxant etc. This review is summarized to understand the chemistry of various derivatives of substituted benzimidazoles with their pharmacological activities.

A new series of 4-(2-chloroquinolin-3-yl)-6-(6-methyl-1H-benzimidazol-2-yl)pyrimidin-2-amine (Va-k) have been synthesized by the reaction of 3-(2-chloroquinolin-3-yl)-1-(6-methyl-1H-benzimidazol-2-yl)prop-2-en-1-one (IVa-k) with guanidine nitrate in ethanol and aqueous solution of sodium hydroxide. The synthesized compounds were characterized by their IR, 1H NMR and Mass spectral studies. The synthesized compounds were evaluated for anthelmintic activity by in-vitro method, against south Indian adult earth worms Pheretima posthuma using Albendazole as a standard drug. Results of the activities reveal that, compounds exhibited moderate to good anthelmintic activity.