Pyrimidines

A new series of 4-(2-chloroquinolin-3-yl)-6-(6-methyl-1H-benzimidazol-2-yl)pyrimidin-2-amine (Va-k) have been synthesized by the reaction of 3-(2-chloroquinolin-3-yl)-1-(6-methyl-1H-benzimidazol-2-yl)prop-2-en-1-one (IVa-k) with guanidine nitrate in ethanol and aqueous solution of sodium hydroxide. The synthesized compounds were characterized by their IR, 1H NMR and Mass spectral studies. The synthesized compounds were evaluated for anthelmintic activity by in-vitro method, against south Indian adult earth worms Pheretima posthuma using Albendazole as a standard drug. Results of the activities reveal that, compounds exhibited moderate to good anthelmintic activity.

An easy solvent-free synthesis of pyrimidine derivatives from aldehydes, aceto acetanilide and urea/thiourea by using fluorspar mineral as catalyst has been described under microwave irradiation. The salient features of this one-pot protocol are short reaction times (4-5 min), excellent yields, cleaner reaction profiles and simple work-up. Also, the catalyst can be reused without any reduction in efficiency.