Ghulam Mohammad Jan

There are a large number of important organic transformations such as oxidation, hydrogenation, hydroformylation, carbonylation, polymerization and various coupling reactions. The majority of these novel catalysts are based on silica, primarily since silica displays many advantageous properties excellent stability (chemical and thermal), high surface area, good accessibility, and organic groups can be robustly anchored to the surface, to provide catalytic centers. In this study we only discuss the catalytic application of schiff base metal complexes in the field of oxidation of phenol, benzyl alcohol, olefin etc

The Complexes of Mn (II) and Cr (II) with amino acid cysteine were synthesized and Characterized by elemental analysis, SEM, TGA. In these complexes the amino acid coordinated to 1:2 with metal and they exhibits octahedral geometry. The catalytic activity of these complexes was studied in olefins using eco-friendly nontoxic molecular oxygen as oxidant.

Pharmaceutical Chemistry combines knowledge of the biological, medical, and physical sciences in the study of the scientific aspect of drug therapy. The emphasis is on the chemical nature of the reactions and interactions involved in drug therapy. The students will receive a solid background in the aspects of chemistry the most relevant to drugs: physical, organic, and analytical chemistry. They will also learn the fundamental aspects of the synthesis, manufacture, use, and mode of action of drugs. Pharmaceutical drug, also referred to as a medicine or medication, can be loosely defined as any chemical substance  - or product comprising such - intended for use in the medical diagnosis, cure, treatment or prevention of disease. 

In this paper we synthesized a natural polymer based metal complex. The complex were characterize using different spectrochemical techniques like FT-IR, Mass spectroscopy and X-ray diffraction etc. The complex was found to be active towards different fungal, MIC80 was determined in vitro in liquid medium by the macro broth dilution method as per the guidelines of CLSI reference document M27-A3 for fungi, document NCCLS/CLSI M11-A6 for gram negative bacteria, and document CLSI M100-S15 for gram positive bacteria.  The order of sensitivity to these compounds was C. albicans > E. coli > S. aureus.

The unique properties associated with these dendrimers such as uniform size, high degree of branching, water solubility, multivalency, well-defined molecular weight and available internal cavities make them attractive for biological and drug-delivery applications. Commercialization of dendrimers is now forthcoming. A new dendrimeric ligand (L) was synthesized by the Michael addition of ethylenediamine to methyl methacrylate. The prepared ligand was complexed Cu (II) ions, the ligand and its complex were characterized by elemental analysis and spectroscopic studies (FT-IR, UV-Vis, 1H NMR and ESI-MS). Square pyramidal geometry was proposed for copper complexes, on the basis of UV-Vis spectroscopic data and molar conductance measurements. The dendrimer metal complex is active towards the oxidation of alcoholic substrates using molecular oxygen as substrate. The effect of various parameters on the rate of reaction is also explained.

Overall, we are convinced that in the future the field of medicinal inorganic chemistry will be a key part of drug development for personalized medicine, allowing also considerable advances in predictive medicine. However, we should also fight against the prejudice associated to metal-based drugs, mostly in terms of in vivo toxicity. Thus, as bioinorganic chemists, we should be able to address the difference between the toxicity related to the “naked”, non-coordinated metal ion, and that of the corresponding metal stabilized by the coordinating ligand(s). Moreover, the toxicity of metal complexes is a multifaceted subject during the development of metal-based drugs as it primarily depends on the type of selected application. In the case of metal-based radiopharmaceuticals for diagnosis or therapy toxicity is not the main matter of concern due to the low concentrations of metal-complexes administered to the patients. In order to exert pharmacological effects (e.g. cisplatin is activated by hydrolysis inside cancer cells), however, further studies are necessary to “fine tune” the stability metal complexes while maintaining their biological activity and reduce their side-effects.

Fe (III) and Cu (II) metal complexes of Schiff base derived from ethylenediamine, succinic acid and formaldehyd. The newly synthesized Schiff base complexes were characterized by elemental analysis, Melting point, conductivity, IR and UV-VIS spectral methods. The absorption spectrum of CrL displayed only one low energy transition centered at 488 nm, which was attributed to 2A1g→2Eg transition indicating its square planer geometry.

In this study we prepare different types of acredinediones derivatives. The derivatives were characterized by using different types of spectra chemical techniques like IR, NMR CHN and mass spectra. The anti-microbial activity was done using diffusion method technique. The antibiotic Streptomycin and Amphotericin was used as a standard for comparative study. All the derivatives were found active and show good antimicrobial activity.

Catalysis is an area of research which still continues to be a premier area of chemistry. It plays a key role in modern chemical technology. There are a large number of important organic transformations such as oxidation, hydrogenation, hydroformylation, carbonylation, polymerization and various coupling reactions. The majority of these novel catalysts are based on silica, primarily since silica displays many advantageous properties excellent stability (chemical and thermal), high surface area, good accessibility, and organic groups can be robustly anchored to the surface, to provide catalytic centers. However, it does have drawbacks it has limited stability in aqueous especially basic conditions, and it cannot easily be formed into membranes or into other forms which could be attached to novel reactors for use in intensive processing applications.

Ni (II) and Mn (II) metal complexes of Schiff base derived from ethylenediamine, succinic acid and formaldehyde. The newly synthesized Schiff base complexes were characterized by elemental analysis, Melting point, conductivity, IR and UV-VIS spectral methods. The complexes have been tested using for the catalytic oxidation of benzylacohol using ecofriendly molecular oxygen as catalyst. The results show that Nickel complex shows highest yield oxidation product as compared to Manganese at 35°C temperature, 90mg catalyst amount and 25 min. time.