Dharmendra Solanki

The present study includes the Formulation and Evaluation of Mucoadhesive Buccal Patch of Timolol Maleate for this study work timolol maleate selected as model drug and using either ionic polymers (SCMC) or non-ionic polymers (carbopol, HPMC).The fabricated patches were prepared by solvent casting method.  The mean thicknesses of the buccal patch formulations were 0.34 – 0.43 mm. Moisture uptake of transdermal patches were found to be 2.94-4.13.which prevents the patches from microbial growth and bulkiness. As amount of PVP increased in every polymer blend, tensile strength and elongation at break were increased. Addition of PVP predominantly decreased the swelling characteristics of the buccal patches, except for SCMC. The drug content of the prepared bioadhesive buccal patches were found in the range of 91.4 - 98.54 %.Bioadhesive strength of buccal patches in following order SCMC >Carbopol>HPMC. The release of Timolol maleate from HPMC patches was slower than SCMC and CP 934.As PVP concentration increased, dissolution rate increases among all polymers. For determination of λmax the solution of the timolol maleate was subjected to ultraviolet scanning in the rage 200 to 400 nm. The λmax was found to be at 294 nm .The pH of formulations was found to be 6.8 - 7.5 which is within the limit of semisolid specifications. The folding endurance of BP formulations was found to be 296 – 325.The results indicated that all formulations were flexible and soft. Bioadhesive buccal patches containing SCMC, HPMC and Carbopol showed a zero order drug release.

The aim of this investigation was to develop and optimize Metformin Hydrochloride matrix tablets for sustained release application. The sustained release matrix tablet of Metformin Hydrochloride was prepared by wet granulation technique using Tamarind pulp polysaccharide. The polysaccharides obtained after extracted from natural source and evaluated for their colour, viscosity and pH. The prepared tablet was evaluated for their hardness, friability, drug content, In vitro dissolution, swelling studies. In vitro drug release profiles of Metformin Hydrochloride Tablet using Tamarind pulp polysaccharide formulation release of drug from the Tablet exhibited a sustained & controlled pattern over an extended time period. .The tablet formulation TF-1 was found to release the drug of about 95% after 12 hrs, The tablet formulation TF-5 was found to release the drug of about 70% after 12 hrs, thus concluded to have sustained drug release for longer period of time in sustained and controlled pattern when compared to other tablet formulations. Using Higuchi’s Model and the Korsmeyer equation, the drug release mechanism from the sustained release tablets was found to be Anomalous (non-Fickian) diffusion. Compatibility study confirmed that interactions do not exist between the drug and polymer.

The aim of this investigation was to develop and optimize Metformin HCl matrix tablets for sustained release application by response surface methodology based on two factor-three response factorial design. The effects of the amounts of polysaccharide from tamarind and polysaccharide from jackfruit in Metformin HCl matrix tablets on the properties of Metformin HCl sustained release matrix tablets drug release was analyzed and optimized. The observed responses were coincided well with the predicted values by the experimental design. The optimized Metformin HCl matrix tablets showed prolonged sustained release of Metformin HCl over 6 hours. These matrix tablets followed the first-order model with anomalous (non-Fickian) diffusion mechanism.