Deepak Prashar

  Nothing in this world is stable and ever accepted. Change is the requirement of nature for the sake of adaptability. However, the pharmaceutical world is also not far off from this change. Technical advancement in pharma world also leads to the development of new dosages forms. This leads to the replacement of the older dosages forms with the newer once. But for the tablet dosages forms this replacement is substituted with modifications. On the top of it the availability of numerous evaluation parameters provides these new modifications in tablets a clear cut demonstration idea.

  From ancient time Allium sativum has been used as food, spice and household medicine for several common problems such as dog bites, insect stings, earaches, burns, wounds, baldness, headaches, chest colds etc. The therapeutic effect of Allium sativum is due to Allin, Allicin, protein, fixed oil, thiamine, ascorbic acid and minerals. This review covers the study of Pharmacognosy, pharmachemistry, pharmacology and pharmaceutical aspects of this herb. Moreover, its valuable medicinal effects along with its economical value are being discussed. 

  In the present research paper, anticonvulsant Sodium valproate tablets were prepared using two different disintegrating agents in different ratio. Acrycoat-L-100 polymer was used as an enteric coating material. The tablets were formulated using direct compression method. Further post formulation parameters like hardness, friability, weight variations and content uniformity were studied. The results suggested, that the prepared enteric coated tablets specifics all the criteria of the standard formulation as per specified in monographs.