anticonvulsant

Drugs  with  large conductance calcium activated potassium channel opening  properties  by  virtue of  their  ability to  promote  an outflow of potassium ions, produce hyper polarization of cell membrane and decrease in the  cell excitability. This modulatory role of BK channels on the glutaminergic neuro-transmission renders BK channels openers potentially useful in epilepsy. Apart from this, channels form the target for modulation for a range of neurotransmitters and have been implicated in the pathogenesis of neurological disorders. Our study was designed to investigate the neurobehavioural and anticonvulsant properties of Cilostazol.  Neurobehavioural properties were evaluated using the hole board, Actophotometer and pentobarbitone-induced hypnosis.  Strychnine and maximal electroshock induced convulsion tests were used to investigate the anti-convulsive actions of Cilostazol. Results show that Cilostazol significantly reduced   the number of poking at both the tested doses. It also reduced the locomotor activity and showed a slight increase in sleeping time also. In addition, Cilostazol (20 & 40 mg/kg) showed protection of rats against strychnine induced convulsions but has no effect on maximal electroshock induced convulsions. The effects of cilostazol in various models were comparable with that of the standard drug.  The findings from the study suggest that the Cilostazol may be neurosedative and anticonvulsant action might be by blocking the inhibitory effects of glycine.

Phenylene-1, 4-oxy-bis-hydantoins have been synthesized from 5-bromohydantoin and substituted quinol (1,4-dihydroxybenzene) in the presence of K2CO3 in dioxane. The structures of newly synthesized compounds have been established on the basis of IR, NMR and Mass spectral data. These compounds were screened for their antibacterial activity against gram +ve and gram – ve bacteria. This phenylene-1, 4-oxy-bis-hydantoins are so far not reported in literature.

Schiff bases represent an important class of organic compounds owing to their wide range of biological activities and industrial applications. They are characterized by the presence of azomethine group and formed by the condensation of primary amines with aldehydes or ketones. They also serve as a back bone for the synthesis of various heterocyclic compounds. Since last few decades, a variety of Schiff bases and their derivatives have been synthesized and reported to possess a wide variety of biological activities i.e. anticancer, antioxidant, antiglycation, antimicrobial, antimalarial, antiviral and CNS activities. This review highlights the synthetic strategies of novel Schiff bases of different heterocycles and their evaluation for different CNS activities. 

In the present research paper, Sodium valproate tablets were prepared by using Syloid FP244 polymer. The tablets were formulated by using wet granulation techniques. Further post formulation parameters like hardness, friability, weight variations and content uniformity were studied. The results suggested, that the prepared enteric coated tablets specifics all the criteria of the standard formulation as per specified in monographs. 

Vanilla planifolia grown for its attractive aroma has rich medicinal value as evidenced by its antimutagenic, antinvasive, anti-metastatic, antinociceptive property and protection against amygdala-kindled seizures. Lack of scientific data authentifying its antiepileptic potential prompted us to evaluate its antiepileptic activity in chemically and electrically induced seizures. Swiss albino mice and Wistar albino rats of either sex (n=6) were induced with seizures using Pentylenetetrazole (PTZ) 60mg/kg i.p. and Maximal electro shock (MES) (50mA for 0.2 seconds) respectively. Sodium valproate 100mg/kg and Phenytoin 25mg/kg served as controls for the respective groups. Vanillin was administered at 100, 200 and 500mg/kg per oral one hour prior to induction of convulsions. The parameters studied include: Onset and duration of tonic flexion and extension, onset of clonic seizure, time for recovery/ death (MES model); Onset of myoclonic jerks and number of episodes (PTZ model). Data were analyzed by one-way ANOVA followed by Dunnet’s test. P < 0.05 was considered as statistically significant. In the MES model, vanillin showed a dose dependent significant decrease in the onset and duration of extension when compared to Phenytoin (P< 0.01). A similar decrease in the onset and duration of flexion was also noted at 100 and 200mg/kg but this was not significant at 500mg/kg dose. In the PTZ induced seizure model, acute administration of vanillin increased latency of onset and decreased the duration of seizures in treated animals as compared to the control. To conclude, the results suggest that vanillin has anticonvulsive property.

  In the present research paper, anticonvulsant Sodium valproate tablets were prepared using two different disintegrating agents in different ratio. Acrycoat-L-100 polymer was used as an enteric coating material. The tablets were formulated using direct compression method. Further post formulation parameters like hardness, friability, weight variations and content uniformity were studied. The results suggested, that the prepared enteric coated tablets specifics all the criteria of the standard formulation as per specified in monographs.