Bipasha Dey Sutradhar

HLA-B27 test is generally positive in spondyloarthritis (SpA) and ankylosing spondylitis (AS). Several anomalous laboratory test results are frequently found in HLA-B27-positive patients. In this study, we intended to evaluate two groups of HLA-B27 positive patients- one group belonging to the 13-40 years age group and another group belonging to the 41-71 years age group. The rationale of this partition was based on the age when AS first emerged and the age when the disease was set up for quite a few years respectively. We anticipate alterations of several familiar laboratory test outcomes between these two groups. After our analysis, we found that in the upper age group, ESR and uric acid are significantly decreased, while SGPT, creatinine, and HbA1C are significantly increased. Other values like ct value in PCR, RA seropositivity, and TC of WBC are decreased a bit in the higher age group; haemoglobin and CRP also marginally increased in this set which are not statistically significant. The plausible explanations behind these changes are discussed.