Afrasim Moin

Oral route is still the preferred route of drug administration for majority of the population as it is non invasive and convenient but has some inherited flaws as certain patients like young children and geriatric patients have difficulty in swallowing. Recent trends are shifting toward design and development of a novel carrier system for existing drugs. Oral disintegrating films (ODF) play an eminent role, as it dissolves rapidly in the mouth and reaches directly into systemic circulation. Various methods have been used for formulating ODF, among which solvent casting is frequently used. The film consists of generally both hydrophilic and hydrophobic polymers and other suitable excipients which either dissolves or disperses rapidly in the oral cavity and releases the active ingredient. The present review is mainly focused on the formulation approaches, their evaluation and therapeutic benefits of ODF.

Curcumin, an orange-yellow colored component of turmeric is a diarylheptanoid. It is the principal curcuminoid obtained from the rhizomes of the Curcuma longa plant (Zingiberaceae). It is a polyphenol product obtained from turmeric. It is been used in some medicinal preparation and even as a food-coloring agent. By the in vivo and in vitro studies it is confirmed that curcumin has antiviral, anti-arthritic anticancer, anti-amyloid, anti-inflammatory and antioxidant properties. The present article highlights the role of curcumin in the treatment of rheumatoid arthritis (RA). It emphasizes on the oral, transdermal and parenteral routes of drug delivery systems and the emerging trends related to these delivery systems such as solid dispersions, cyclodextrin inclusion compounds, solid lipid nanoparticles, liposomes, micro nano emulsions, transdermal patches, topical gel and proniosomes etc.

Polymer grafting open a new window to pharmaceutical formulation. This article review about the different natural polymer and their application in pharmaceutical industry. Techniques such as grafting, crosslinking, blending and composite formation techniques are accustomed to modify the polymer. Recently, polymer grafting method received a wide attention than the other methods employed in the modification of the polymer. Polymer grafting can be achieved by covalent bonding of monomer to the polymer. In this review, techniques such as chemical grafting, radiation grafting etc. are also discussed.

Training is the attainment of knowledge, skills, and competencies as an outcome of the teaching of vocational or practical skills and knowledge that relate to specific useful competencies. Training in a regulated environment is a continuous process that should be adaptable from a single business unit to an entire organization. Training entails providing, developing, and reconfirming knowledge, skills and core competencies to meet business requirements. This paper will create a framework by which specific requirements for setting up and maintaining an effective and complaint training program are explained by providing overview of vital training topics.