Adienbo O

The present work was designed to investigate the anti-ulcer activities of methanolic extract of artocarpusaltilis [breadfruit] on alcohol induce ulcer in male albino rats. Animals were administered orally with a single dose of 98‰ alcohol [depending on the animals’ weight] to induce ulcer. This resulted in significant increase in ulcer occurrence [exacerbation]. Both the induced and normal rats were divided into six groups of 5 rats each. Group 1 was the control group [induced but not treated] while group 2 received 100mg/kg dose of aqueous extract of artocarpusaltilis. Group 3 and 4 received 200mg/kg and 300mg/kg dose of aqueous extract of artocarpusaltilis respectively. Group 5 received 10mg/kg per oral dose of omeprazole [standard drug]. Administration of methanolic extract of artocarpusaltilis produce a decrease in ulcer occurrence in induced rats. The decrease in ulcer occurrence was significant [p‹0.005] with all the groups treated with methanolic extract of artocarpusaltilis when compared to the control group. But group 3 and 4 exclusively showed same potency when compared to group 5 [standard drug]. The decrease in ulcer incidence when compared to the control group [ulcer induced but not treated] and for exhibiting same potency with the standard drug shows that the extract of artocarpusaltilis  is effective in controlling ulcer and can be used as a substitute for the standard drug in managing or treating/controlling ulcer. Conclusively, methanolic extract of artocarpusaltilis has tremendous beneficial anti-ulcer values in the treatment of ulcer following oral administration.

In the present study, the effects of pre-treatment with catecholamine on indomethacin-induced ulcer were studied. Rats were exposed to various treatments with epinephrine and dopamine 30 minutes before ulcer was induced using NSAID (indomethacin). Experimental ulceration was induced in fasted rats using Indomethacin (40mg/kg.p.o). Four hours later after indomethacin administration, the stomachs were opened under thiopentane anesthesia and the ulcer area scored by planimetry. Sections of the stomachs were prepared for histology and stained for apoptotic cell count. Acid secretion was also studied in the control and treated animals by pylorus ligation technique. Indomethacin treatment resulted in the formation of ulcer with ulcer index of 5.0±0.5 while the pre-treatment with catecholamine significantly reduced ulceration episodes (epinephrine: ulcer index=3.0±0.7, dopamine: ulcer index=2.0±0.7, p